NCT06537557 Application of an Early In-Hospital Temperature Management Protocol for Heat Stroke Patients
| NCT ID | NCT06537557 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Second Affiliated Hospital, Zhejiang University, School of Medicine |
| Condition | Heat Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 188 participants |
| Start Date | 2024-07-01 |
| Primary Completion | 2026-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 188 participants in total. It began in 2024-07-01 with a primary completion date of 2026-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Heat stroke is a life-threatening clinical syndrome characterized by an imbalance between heat production and heat dissipation in the body, resulting from exposure to hot and humid environments and/or strenuous exercise. It is defined by an elevated core temperature exceeding 40°C and central nervous system abnormalities, accompanied by multi-organ dysfunction. The severity of cellular and tissue damage in heat stroke patients depends on the peak temperature reached and the duration of hyperthermia. Rapid reduction of core temperature can halt cellular damage, quickly reverse organ dysfunction, and improve patient outcomes. Therefore, early identification and rapid cooling are crucial to prevent irreversible damage and death in heat stroke patients. However, there is a lack of systematic and specific protocols to guide emergency medical staff in the standardized and effective management of body temperature in heat stroke patients. To address this, our research team previously developed an early in-hospital temperature management protocol for heat stroke patients based on the best available evidence, expert consultations, and expert panel meetings. This study aims to validate the feasibility and effectiveness of the protocol through clinical research, providing a basis for clinical practice.
Eligibility Criteria
Inclusion Criteria: * Patients admitted to the emergency department and diagnosed with heat stroke according to the China expert consensus on Heat Stroke Exclusion Criteria: * transferred from another hospital and body temperature \< 39.5℃; discharged within 4 hours, and subsequent body temperature or outcomes were unavailable; required immediate cardiopulmonary resuscitation; had other serious diseases, such as massive cerebral haemorrhage or severe trauma.
Contact & Investigator
lan chen
STUDY CHAIR
Second Affiliated Hospital, Zhejiang University, School of Medicine
Frequently Asked Questions
Who can join the NCT06537557 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Heat Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06537557 currently recruiting?
Yes, NCT06537557 is actively recruiting participants. Contact the research team at fengxiuqin@zju.edu.cn for enrollment information.
Where is the NCT06537557 trial being conducted?
This trial is being conducted at Guli, China, Dongyang, China, Hanzhou, China, Jinhua, China and 3 additional locations.
Who is sponsoring the NCT06537557 clinical trial?
NCT06537557 is sponsored by Second Affiliated Hospital, Zhejiang University, School of Medicine. The principal investigator is lan chen at Second Affiliated Hospital, Zhejiang University, School of Medicine. The trial plans to enroll 188 participants.
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