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Recruiting EARLY_Phase 1 NCT05024760

Antiseptic Effects on the Dental Implant Internal Surface Microbiome

Trial Parameters

Condition Peri-Implantitis
Sponsor Madigan Army Medical Center
Study Type INTERVENTIONAL
Phase EARLY_Phase 1
Enrollment 150
Sex ALL
Min Age 18 Years
Max Age 55 Years
Start Date 2022-07-28
Completion 2025-11
Interventions
ChlorhexidineHydrogen Peroxide

Brief Summary

Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.

Eligibility Criteria

Inclusion Criteria: * Active duty military * 18-55 years old * Over 6 months remaining at local duty station Exclusion Criteria: * Tobacco user * Medications that affect soft tissue or bone healing * Metabolic disorder that affects soft tissue or bone healing * Active periodontal disease

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