NCT06533215 Antimicrobial Efficacy of Nano-Based ICM on E.F
| NCT ID | NCT06533215 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Tanta University |
| Condition | Enterococcus Faecalis Infection |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2024-01-02 |
| Primary Completion | 2025-02-02 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This in-vivo study aims to evaluate the antimicrobial effect of nano based intracanal medications (Triple antibiotic-loaded chitosan nanoparticles and chlorohexidine loaded by silver nanoparticles) on Enterococcus faecalis count reduction in secondary endodontic infection cases.
Eligibility Criteria
Inclusion Criteria: * Single rooted, single canal premolar teeth. * Teeth indicated for non-surgical root canal retreatment. * Teeth have signs and/or symptoms of post-treatment disease manifested by recurrent acute and/or chronic periapical abscess. * Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula. * Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament. * Symptomatic or asymptomatic teeth with short root canal filling indicated for prosthetic restoration Exclusion Criteria: * Patients with any systemic diseases. * Pregnant or lactating patients. * Immunocompromised patients. * Non-restorable tooth. * Calcified root canal. * Teeth with root fracture. * Teeth with periodontal pocket deeper than 4mm. * Teeth have procedural error like ledge, broken instrument, or perforation