NCT06982209 ANI-Guided Anesthetic Desflurane Consumption
| NCT ID | NCT06982209 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Wonkwang University Hospital |
| Condition | Postoperative Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 125 participants |
| Start Date | 2026-07-02 |
| Primary Completion | 2026-07-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 125 participants in total. It began in 2026-07-02 with a primary completion date of 2026-07-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
General anesthesia requires precise titration of inhaled anesthetics like desflurane and opioids like remifentanil to balance sedation, analgesia, and hemodynamic stability. The Analgesia/Nociception Index (ANI), derived from heart rate variability (HRV), quantifies parasympathetic tone to assess nociception-antinociception balance on a 0-100 scale, with lower values indicating nociceptive stress. ANI analyzes high-frequency HRV components, reflecting parasympathetic inhibition during painful stimuli, making it a reliable indicator of intraoperative nociception. Studies validate the utility of ANI in detecting nociceptive events during laparoscopic surgery. ANI-guided opioid titration reduces opioid consumption and stabilizes hemodynamics, enhancing perioperative outcomes.
Eligibility Criteria
Inclusion Criteria: * aged 19-65 years, American Society of Anesthesiologists (ASA) physical status I-II, scheduled for elective laparoscopic cholecystectomy under general anesthesia. Exclusion Criteria: * chronic pain, preoperative opioid use, cardiac arrhythmias, autonomic dysfunction, or contraindications to desflurane or remifentanil.
Contact & Investigator
Cheol Lee, M.D.,Ph.D
PRINCIPAL INVESTIGATOR
Wonkwang University Hospital
Frequently Asked Questions
Who can join the NCT06982209 clinical trial?
This trial is open to participants of all sexes, aged 19 Years or older, up to 65 Years, studying Postoperative Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06982209 currently recruiting?
Yes, NCT06982209 is actively recruiting participants. Contact the research team at ironyii@wku.ac.kr for enrollment information.
Where is the NCT06982209 trial being conducted?
This trial is being conducted at Iksan, South Korea.
Who is sponsoring the NCT06982209 clinical trial?
NCT06982209 is sponsored by Wonkwang University Hospital. The principal investigator is Cheol Lee, M.D.,Ph.D at Wonkwang University Hospital. The trial plans to enroll 125 participants.