NCT07299591 Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Hip Infection: a Microdialysis Study
| NCT ID | NCT07299591 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Bonn |
| Condition | Periprosthetic Hip Infection |
| Study Type | OBSERVATIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-11-15 |
| Primary Completion | 2026-11-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 30 participants in total. It began in 2025-11-15 with a primary completion date of 2026-11-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to use the technique of microdialysis to analyse the intraarticular space of the hip joint after removal of a periprosthetic joint infection affected endoprosthesis and implantation of an antibiotic-containing cement spacer over the entire period of the first hospitalization (usually 14 days) to closely monitor pharmacological and immunological aspects. In detail, antibiotic concentrations in the joint cavity and systemic circulation will be assessed according to reinfection rates, infection-free survival and fucntional outcome over a 12-month folluw-up period.
Eligibility Criteria
Inclusion Criteria: * clinical indication for two-stage revision of hip PJI * approval for surgery by the orthopedic and anesthesiologic department * being over 18 years of age * written, informed consent after detailed patient information about the study protocol and possible study dependent risks Exclusion Criteria: * \- known allergies to antibiotics gentamicin and vancomycin used within the spacer
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07299591 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Periprosthetic Hip Infection. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07299591 currently recruiting?
Yes, NCT07299591 is actively recruiting participants. Contact the research team at alexander.franz@ukbonn.de for enrollment information.
Where is the NCT07299591 trial being conducted?
This trial is being conducted at Bonn, Germany.
Who is sponsoring the NCT07299591 clinical trial?
NCT07299591 is sponsored by University Hospital, Bonn. The trial plans to enroll 30 participants.