Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia
Trial Parameters
Brief Summary
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear. In this study, the local field potential (LFP) from the deep brain nuclei and the scalp electroencephalogram (EEG) of the frontal cortex were recorded from patients undergoing deep brain stimulation (DBS) surgery during the recovery from general anesthesia, in order to explore the changes and relevance of deep brain nuclei firing and cortex activity during the recovery of consciousness from general anesthesia .
Eligibility Criteria
Inclusion Criteria: * 18-75 years old * ASA (American Society of Anesthesiologists) classification I-III * Those who meet the indications for DBS surgery * Right-handed with normal listening and speaking abilities * The patient signs the informed consent form and cooperates with the researchers Exclusion Criteria: * Patients with cognitive impairment \[Montreal Cognitive Assessment (MoCA) score less than 26 points\]; * Patients with severe depression \[Beck Depression Inventory (BDI-II) score greater than or equal to 25 points\]; * Patients with important organs dysfunction, such as heart, lungs, liver, and kidneys; or patients with unstable vital signs; * Patients who are expected to enter the ICU after surgery; * Patients who are alcoholic, alcohol dependent or drug dependent; * Patients who have received general anesthesia one month before surgery, patients who are known to be allergic to general anesthetics; * The DBS surgery exceeds 4 hours; * Patients who are pregnant.