NCT05751863 Analgesia-First Sedation in Trauma Patients
| NCT ID | NCT05751863 |
| Status | Recruiting |
| Phase | — |
| Sponsor | MemorialCare Health System |
| Condition | Mechanical Ventilation |
| Study Type | INTERVENTIONAL |
| Enrollment | 170 participants |
| Start Date | 2023-04-01 |
| Primary Completion | 2026-03-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 170 participants in total. It began in 2023-04-01 with a primary completion date of 2026-03-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study's aim is to ascertain the best approach for providing sedation and pain management for patients who have sustained trauma and are requiring respiratory support from a mechanical ventilator. The common approach to patients who need mechanical ventilation is to provide continuous drips of sedatives and pain medicine and awaken the patient once a day to check the brain functions. Another approach is to provide pain medicine and reserve sedatives for only a short duration when needed. The difference between approaches has not been studied in Trauma patients.
Eligibility Criteria
Inclusion Criteria: 1. ≥ 18 years of age 2. Mechanically ventilated with an expected duration of MV ≥ 48h 3. Initiated continuous sedative/analgesic infusions by the ICU team 4. Patient is a candidate for MV weaning Exclusion Criteria: 1. Admission after resuscitation from cardiac arrest 2. Significant neurological deficit due to a chronic disorder 3. History of alcohol dependence and/or other illicit drug abuse 4. Prior administration of continuous sedative/analgesic from a transferring institution 5. Patient receiving neuromuscular blocking agents 6. Allergy to midazolam, lorazepam, and/or propofol
Contact & Investigator
Maged Tanios, MD, MPH
PRINCIPAL INVESTIGATOR
Long Beach Memorial Medical Center
Frequently Asked Questions
Who can join the NCT05751863 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Mechanical Ventilation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05751863 currently recruiting?
Yes, NCT05751863 is actively recruiting participants. Contact the research team at tanios@memorialcare.org for enrollment information.
Where is the NCT05751863 trial being conducted?
This trial is being conducted at Long Beach, United States.
Who is sponsoring the NCT05751863 clinical trial?
NCT05751863 is sponsored by MemorialCare Health System. The principal investigator is Maged Tanios, MD, MPH at Long Beach Memorial Medical Center. The trial plans to enroll 170 participants.