Trial Parameters
Brief Summary
1. Establish a multimodality imaging database for PVD, improve the one-stop screening process for early PVD based on artificial intelligence, build a full-cycle control information platform, and promote the construction and standardization of a multidisciplinary co-morbidity and co-management diagnosis and treatment model. 2. Based on non-invasive, zero-contrast ocular OCTA combined with one-stop CTA imaging of the heart and brain, construct an integrated "eye-heart-brain" early warning model for PVD, and explore a potential non-invasive and convenient early warning system for PVD. 3. Based on the multi-omics, investigate EVs-mediated intercellular communication network, elucidate the roles and regulatory mechanisms of EVs in the development of PVD, search for potential targets for intervention, and construct an artificial intelligence-based "pan-vascular score" risk assessment system based on the combination of multi-modality imaging and multi-omics biomarkers.
Eligibility Criteria
Inclusion Criteria: Task 1: 1. Patients with coronary artery disease (≥50% stenosis in any coronary artery on coronary angiography) 2. Age ≥18 years old 3. Proposed OCT-IVUS integrated imaging system 4. able to provide written informed consent prior to the start of any procedures related to the study. Task 2: 1. patients with coronary artery disease (coronary angiography reveals ≥50% degree of stenosis in any coronary artery) and patients with stroke or TIA (confirmed by a neurologist) 2. Age ≥ 18 years 3. able to provide written informed consent prior to the start of any procedures related to the study. Exclusion Criteria: Task 1: 1. severely tortuous/calcified coronary arteries with anticipated difficulty in completing the OCT-IVUS integrated imaging system 2. uncontrolled congestive heart failure or acute left heart failure;plan 3. claustrophobia; 4. left main stem occlusion; 5. proposed coronary artery bypass grafting (CABG); 6. uncontrolled severe ventricular arrhythmia; 7. active