NCT07591649 Adapt NK for High Risk Myeloid Diseases as Bridge to Allo HSCT
| NCT ID | NCT07591649 |
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Sponsor | Masonic Cancer Center, University of Minnesota |
| Condition | Relapsed Adult AML |
| Study Type | INTERVENTIONAL |
| Enrollment | 18 participants |
| Start Date | 2026-05-08 |
| Primary Completion | 2030-03-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 18 participants in total. It began in 2026-05-08 with a primary completion date of 2030-03-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a multi-institutional Phase I/II study of an allogeneic KIR-HLA mismatched NK cell infusion (AdaptNK) and a short course of subcutaneous interleukin-2 (IL-2) administered after lymphodepleting chemotherapy \[cyclophosphamide (CY)/fludarabine (FLU)\] in patients with relapsed or refractory acute myelogenous leukemia (AML). AdaptNK is a natural killer (NK) cell product that is enriched for NK cells with an "adaptive", or human cytomegalovirus (CMV)-induced, phenotype.
Eligibility Criteria
Inclusion Criteria: * 18-74 years with Karnofsky score ≥ 70% * 75 years and older: KPS ≥ 70%, HCT-CI \< 5 (excluding history of solid tumor), AND not frail by Fried frailty criteria (see Appendix III) * HLA type C1/C1 or C2/C2 Note: For easy determination, the definition of HLA-C ligand group assigments is included below: HLA-C1 group alleles are defined as HLA-C01, C03, C07, C08, C12, C14, C16 HLA-C2 group alleles are defined as HLA-C02, C04, C05, C06, C15, C17, C18 * adequate liver, renal, pulmonary and cardiac function * ability to be off glucocorticoids and other immunosuppressive medications indicated for acute or chronic GVHD for at least 28 days prior to the AdaptNK cell infusion * There must be sufficient time between the most recent therapy and the screening bone marrow as delineated below: * anti-leukemic systemic cytotoxic chemotherapy - 2 weeks * Targeted anti-leukemic agents (FLT-3, IDH, menin inhibitors) - 3 half-lives of the medication * Radiotherapy - 1 week * donor lymphocyte infusions - 6 weeks * hematopoietic growth factors (filgrastim, TPO agonists, EPO) - 1 week * biologic therapy (monoclonal antibodies, T-cell engagers) - 2 weeks * Immune effector cellular therapy - 4 weeks * Intrathecal chemotherapy for treatment of active CNS leukemia - there must be at least two CSF samples negative for leukemia separated by one week before enrollment. * WBC shall be \< 25,000 before infusion. Hydroxyurea is permitted until day -3 to control excess blast proliferation. No other systemic treatment is allowed after the screening bone marrow is performed for inclusion in protocol * All prior treatment related toxicities should have resolved to ≤ grade 1 prior to study enrollment * agrees to use of adequate contraception from study enrollment to 4 months after cell infusion * voluntary written consent Exclusion Criteria: * Myeloid neoplasms with known or strongly suspected germline background, except DDX41, TP53, or RUNX1. * Acute promyelocytic leukemia (APL) * myocardial infarction (MI) within previous 6 months of study enrollment * pregnant or breastfeeding * Active CNS involvement with AML * new or progressive pulmonary infiltrates * active autoimmune disease requiring immunosuppressive therapy * Preexisting inflammatory disease requiring immunosuppressive therapy * history of severe asthma and currently on chronic systemic medications * HIV-1/2 positivity or hepatitis C/B * active systemic infections requiring anti-infective treatment * received any investigational agent within the 14 days before the start of study treatment (1st dose of fludarabine) * Patients with second malignancies are excluded if they have required systemic cytotoxic chemotherapy within 1 year or if they are not in remission * Exception: patients that are on stable dosing of hormonal therapy (e.g. aromatase inhibitor or antiandrogen therapy) for active breast or prostate cancer for 1 year are eligible. * Patients with excised basal cell or squamous cell carcinoma of the skin are eligible. * Patients with excised carcinoma in situ of the cervix or breast are eligible. * Patients with untreated T1a or T1b prostate cancer are eligible.
Frequently Asked Questions
Who can join the NCT07591649 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Relapsed Adult AML. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07591649 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT07591649 currently recruiting?
Yes, NCT07591649 is actively recruiting participants. Visit ClinicalTrials.gov or contact Masonic Cancer Center, University of Minnesota to inquire about joining.
Where is the NCT07591649 trial being conducted?
This trial is being conducted at Minneapolis, United States.
Who is sponsoring the NCT07591649 clinical trial?
NCT07591649 is sponsored by Masonic Cancer Center, University of Minnesota. The trial plans to enroll 18 participants.