NCT07156565 Actinium Therapy for Late-stage Aggressive Sarcomas
| NCT ID | NCT07156565 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | Ratio Therapeutics, Inc. |
| Condition | Advanced Soft Tissue Sarcoma |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-11-12 |
| Primary Completion | 2028-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 30 participants in total. It began in 2025-11-12 with a primary completion date of 2028-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to learn about the safety of drug \[Ac225\]RTX-2358 and the diagnostic imaging agent \[Cu64\]LNTH-1363S. Additionally Ratio Therapeutics will learn if \[Ac225\]RTX-2358 drug is effective in treating advanced sarcoma. The main questions the study aims to answer in Phase/Part 1 of the trial are: * Is \[Ac225\]RTX-2358 tolerable or does it cause toxicities (medical problems) in patients. * What is the most tolerable dose of \[Ac225\]RTX-2358 * Does the treatment show effectiveness on advanced sarcoma Participants will: * Take drug \[Ac225\]RTX-2358 once every 8 weeks (4 cycle target; 6 cycle maximum) over a period of 12 months * Visit the clinic three times for the first week of cycle one, then once a week for the remaining 7 weeks of cycle 1 for check-ups and tests. * For cycles 2-6: patient will visit the clinic once every 2 weeks for checkups and tests * Remain in long term follow-up for a period of four additional years
Eligibility Criteria
Inclusion Criteria: * 18 years of age or older. * History of relapse and refractory soft tissue sarcoma. 1. Histological confirmation of sarcoma at any point since diagnosis 2. At least 1 prior treatment regimen * Measurable disease as per RECIST (v1.1) for soft tissue sarcoma that is also positive on FAPi PET/CT or PET/MRI scan. * ECOG performance status of 0 or 1. * Adequate Organ reserve and renal function as evidenced by: 1. Neutrophil count ≥ 1200 µL without granulocyte colony stimulating factor 2. Platelet count ≥ 100,000 µL 3. Hemoglobin ≥ 8 g/dL 4. Total bilirubin level ≤ 1.5 × upper limit of normal (ULN). 5. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × ULN. 6. Calculated creatinine clearance ≥ 60 mL/min. 6. Coagulation parameters (prothrombin time, international normalized ratio and activated partial thromboplastin time) ≤ 1.5 × ULN 7. All patients (males and females of childbearing potential) must agree to practice 2 forms of highly effective contraceptive precautions to prevent pregnancy from the time consent is signed and throughout the trial. 8\. The patient or the patient's legal representative must be willing and able to provide written informed consent. Exclusion Criteria: * History of whole pelvic irradiation. * History of radioligand therapy. * Treatment within 14 days prior to first administration with: 1. Palliative surgery or external beam radiation. 2. Approved anticancer therapy including chemotherapy or immunotherapy. 3. Any investigational therapy. 4. Any major surgery (e.g., requiring general anesthesia). * Patients who are scheduled for external beam radiation therapy or radioligand therapy during the study period. * Congestive heart failure \> Class II New York Heart Association Functional Classification, current pericarditis, myocardial infarction within 6 months, or symptomatic coronary artery disease. * Patients with uncontrollable incontinence. * Unstable or clinically significant concurrent medical condition that would, in the opinion of the Investigator, jeopardize the safety of a patient and/or their compliance with the protocol. * Active infection requiring systemic antibacterial/antibiotic, antifungal, or antiviral therapy. Chronic antiviral therapy for stable viral disease can be included. * History of active fibrotic condition. * Any active malignancy other than sarcoma that requires treatment. * Stable brain metastasis is allowed but documented untreated metastases to brain or meninges are excluded. * Currently pregnant or lactating. * Known allergy to any of the study drugs or their excipients. * Inability or unwillingness to comply with any of the required imaging studies or study assessments.
Frequently Asked Questions
Who can join the NCT07156565 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Advanced Soft Tissue Sarcoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07156565 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT07156565 currently recruiting?
Yes, NCT07156565 is actively recruiting participants. Visit ClinicalTrials.gov or contact Ratio Therapeutics, Inc. to inquire about joining.
Where is the NCT07156565 trial being conducted?
This trial is being conducted at Los Angeles, United States, Rochester, United States, New York, United States, Cleveland, United States and 2 additional locations.
Who is sponsoring the NCT07156565 clinical trial?
NCT07156565 is sponsored by Ratio Therapeutics, Inc.. The trial plans to enroll 30 participants.