NCT07198594 Accelerated rTMS Therapeutic Approach for Refractory Obsessive-Compulsive Disorder
| NCT ID | NCT07198594 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University |
| Condition | Obsessive Compulsive Disorder (OCD) |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2025-07-03 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2025-07-03 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to learn if individualized accelerated repetitive transcranial magnetic stimulation (rTMS) targeting the inferior frontal cortex combined with symptom provocation works to treat obsessive-compulsive disorders (OCD) in adults. It will also learn about the safety of rTMS over right IFC. The main questions it aims to answer are: * Does rTMS using a new individualized IFC target relieve participants' OCD symptoms? * What medical problems do participants have when taking rTMS? Participants will: * Take rTMS six times per day for 5 consecutive days * Visit the clinic once at baseline, the day and four weeks after treatment for checkups and tests
Eligibility Criteria
Inclusion Criteria: * Volunteer subjects with Obsessive Compulsive Disorders (OCD) according to the Diagnostic and Statistical Manual of Mental Disorders (DSM V) criteria * without associated tics ("Gilles de la Tourette" Syndrome) * Age 18-60 years, right-handed * Disease severity: Yale-Brown Obsessive Compulsive Scale score ≥16 for OCD patients * Medication stable for at least 4 weeks * Resistant patients to standard treatments: partial but insufficient response (reduction of Y-BOCS score \< 35%) or lack of response to previous well conducted treatment including: optimal tolerated dose and adequate duration (\> 12 weeks) of at least 2 Serotonin Reuptake Inhibitors (selective serotonin reuptake inhibitors, clomipramine), or 1 Serotonin Reuptake Inhibitors + 1 augmentation strategy (adjunction of an antipsychotic - such as risperidone or olanzapine or aripiprazole - or lithium or buspirone) * No systematic rTMS therapy in the past six months; * Signature of informed consent form; * Normal vision or corrected vision; * Capacity to complete protocol-specified tests. Exclusion Criteria: * Abnormal cognitive status (assessed using MoCA with score \<24); * Other primary diagnosis than OCD (comorbid mild depression is tolerated) * Comorbid diagnosis of schizophrenia/ psychotic disorder, bipolar disorder, substance abuse or dependance3) * Significant self-harm intent or severe suicidal tendencies within the past year; * Irreversible visual or auditory impairment preventing completion of scales or related assessments; * Presence of metallic implants, such as pacemakers or stents; * Any current or potential medical, psychological, social, or geographical factors compromising patient safety or study participation; * Poor compliance; * Claustrophobia; * History of epilepsy or familial epilepsy * Pregnant or lactating women (women of childbearing potential must obtain a negative pregnancy test result prior to study commencement and employ medically approved contraceptive measures); * Deterioration or failure of vital organ function (cardiac, pulmonary, hepatic, renal, etc.); or unstable vital signs; * Conditions unsuitable for this stimulation site, such as increased intracranial pressure, elevated intraocular pressure, or glaucoma * History of or concomitant neurological disorders: cerebrovascular disease, central nervous system infections, Creutzfeldt-Jakob disease, Huntington's disease and Parkinson's disease, Lewy body dementia, traumatic brain injury dementia, other physical/chemical factors (drugs, alcohol, CO, etc.), significant somatic diseases (hepatic encephalopathy, pulmonary encephalopathy, etc.), intracranial space-occupying lesions (subdural haematoma, brain tumours), endocrine system disorders (thyroid disease, parathyroid disease), and dementia caused by vitamin deficiency or any other cause
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07198594 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Obsessive Compulsive Disorder (OCD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07198594 currently recruiting?
Yes, NCT07198594 is actively recruiting participants. Contact the research team at yj_zhao@tongji.edu.cn for enrollment information.
Where is the NCT07198594 trial being conducted?
This trial is being conducted at Shanghai, China.
Who is sponsoring the NCT07198594 clinical trial?
NCT07198594 is sponsored by Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University. The trial plans to enroll 20 participants.