Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
Trial Parameters
Brief Summary
The purpose of this study is to investigate the effectiveness of accelerated intermittent theta-burst transcranial magnetic stimulation (aiTBS) in inducing anti-depressant responses in individuals with treatment-resistant depression of bipolar II disorder. This is a double-blind, randomized, sham-controlled trial that targets a single location on the left dorsolateral prefrontal cortex (LDLPFC) using the MagPro rTMS system.
Eligibility Criteria
Inclusion Criteria: 1. Participants aged 18 years old to 80 years old with a primary diagnosis of bipolar affective disorder II in a current major depressive episode, according to the criteria defined in the Diagnosis and Statistical Manual of Mental Disorders, Fifth Fourth Edition, Text Revision (DSM-V). 2. Able to read, understand, and provide written, dated informed consent prior to screening. Participants will be deemed likely to comply with study protocol and communicate with study personnel about adverse events and other clinically important information. 3. Meet the criteria by Maudsley Staging Method score \>=7 4. Not in a current state of hypomania (as assessed by the Young Mania Rating Scale) or psychosis 5. In good general health, as ascertained by medical history. 6. Must have a stable psychiatrist during study enrollment, who confirms diagnosis of bipolar II disorder. 7. Must be on a mood stabilizer regimen for 6 weeks prior to study enrollment and agree to continue this re