Abdominal Aortic Aneurysm Stabilization With Truncal Cells: Controlled Clinical Trial With Historical Cohorts
Trial Parameters
Brief Summary
Phase IIa, single-center clinical trial compared with historical cohorts to evaluate the preliminary safety and efficacy of an allogeneic adipose tissue-derived mesenchymal stem cells infusion in an aneurysmal sac for the treatment of AAA.
Eligibility Criteria
Inclusion Criteria: 1. Subjects with AAA greater than 5 cm diameter with endovascular treatment indication, analyzed by aortic AngioCT. 2. Subjects ≥ 18 years at the time of inclusion. 3. Subjects with a good infrarenal neck for a standard device placement, neither fenestrated nor branched. 4. Patients with an estimated life expectancy greater than 2 years at the time of inclusion. 5. Women with childbearing capacity must have a negative pregnancy test at the time of inclusion and must agree to use highly effective contraceptive methods (diaphragms plus spermicide or male condom plus spermicide, oral contraceptive combined with a second method contraceptive implant, injectable contraceptive, permanent intrauterine device, sexual abstinence or partner with vasectomy) during their study participation. 6. The patient must be able to attend all study visits and comply with all study procedures. Exclusion Criteria: 1. Patients with unresolved neoplasia history or hematologic disease. 2. Pat