A Study of Teclistamab and Mezigdomide in People With Multiple Myeloma
Trial Parameters
Brief Summary
The researchers are doing this study to find out whether combining teclistamab and mezigdomide is a safe and effective treatment approach in people with relapsed/refractory multiple myeloma (MM).
Eligibility Criteria
Inclusion Criteria: 1. Patients with relapsed or refractory multiple myeloma who have been treated with a proteasome inhibitor, an IMiD, and an anti-CD38 antibody. Patients who have been treated with at least 2 prior lines of therapy are eligible. Multiple myeloma is defined by the International Myeloma Working Group (IMWG) updated criteria. 2. Patients need to have measurable disease defined by one or more of the following: 1. Serum myeloma (M)-protein greater than or equal to 0.5 g/dL (5 g/L). 2. Urine M-protein greater or equal to 200 mg/24 h. 3. Involved light chain (either kappa or lambda) \>10 mg/dL with an abnormal kappa: lambda ratio 4. Plasmacytoma(s) that is new or definitely increased verified by imaging or biopsy. Increase is defined as a 50% and at least 1 cm increase as measured serially by the sum of the products of the cross-diameters of the measurable lesion. 5. A bone marrow biopsy demonstrating \>30% infiltration of clonal plasma cells. 3. Patients who have received