A Study of Talquetamab for People With Multiple Myeloma Who Have Received BCMA CAR T-Cell Therapy
Trial Parameters
Brief Summary
The researchers are doing this study to find out whether talquetamab is an effective treatment after BCMA CAR Tcell therapy for people with relapsed or refractory multiple myeloma. All participants in this study will have already received the BCMA CAR T-cell therapy ide-cel for their disease.
Eligibility Criteria
Inclusion Criteria: * Patient with multiple myeloma who has received prior treatment with an IMID, PI, and a CD38 monoclonal antibody * Received treatment with an FDA approved BCMA CART cell therapy ide-cel within 1-3 months prior to enrollment * Serum monoclonal protein \< 0.5 gm/dL; 24-hour urine monoclonal protein \< 200 mg; and serum involved free light chains \< 10 mg/dL * No evidence of disease progression based on IMWG criteria * ≥18 years of age at the time of signing informed consent. * ECOG performance status of 0 or 1 * Recovered to Grade 1 or baseline of any non-hematologic toxicities due to prior treatments, excluding Grade 2 neuropathy and Grade 2 alopecia. * No evidence of ongoing, any grade cytokine release syndrome or immune effector cell mediated neurotoxicity * No additional myeloma therapies after the CART cell therapy * Absolute neutrophil count (ANC) ≥ 1,000/mm\^3 without growth factor support for 7 days for G-CSF or GM-CSF and for 14 days for pegylated GCSF prior