← Back to Clinical Trials
Recruiting Phase 1 NCT05985148

A Study of Stereotactic Radiosurgery (SRS) to Treat Pain in the Chest and/or Stomach Wall

Trial Parameters

Condition Thoracoabdominal Wall Pain
Sponsor Memorial Sloan Kettering Cancer Center
Study Type INTERVENTIONAL
Phase Phase 1
Enrollment 18
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2023-08-02
Completion 2028-08
Interventions
Single-fraction stereotactic radiosurgery (SRS)

Brief Summary

The researchers are doing this study to find out whether stereotactic radiosurgery (SRS) is a safe, practical (feasible), and effective treatment for people with chronic TAWP. The researchers will test different doses of SRS to find the highest dose that causes few or mild side effects.

Eligibility Criteria

Inclusion Criteria: * Patients must have a documented history of chronic (≥ 3 months) thoracoabdominal wall pain (TAWP) attributable to ≤ 3 unilateral spinal levels as confirmed by diagnostic paravertebral nerve block or TENS (if results of the paravertebral nerve block are inconclusive) performed by an attending anesthesiologist specializing in pain management prior to study enrollment. * Patients must have TAWP that is inadequately relieved by a trial of conventional pharmacologic therapy (defined as NRS pain score ≥ 4/10 while on treatment with conventional pharmacologic therapy for analgesia) as determined by an attending physician specializing in pain management. * KPS ≥ 60% * Age ≥ 18 years old Exclusion Criteria: * Patients with a life expectancy of \< 6 months as predicted by the Adult Comorbidity Index (ACE-27, see Appendix 1) * Patients with active autoimmune connective tissue disease * Patients with bilateral TAWP * Patients with preexisting pneumothorax * Patients with pree

Related Trials