NCT05487170 A Study of RNK05047 in Subjects With Advanced Solid Tumors/Diffuse Large B-cell Lymphoma (CHAMP-1)
| NCT ID | NCT05487170 |
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Sponsor | Ranok Therapeutics (Hangzhou) Co., Ltd. |
| Condition | Advanced Solid Tumor |
| Study Type | INTERVENTIONAL |
| Enrollment | 32 participants |
| Start Date | 2022-07-12 |
| Primary Completion | 2025-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 32 participants in total. It began in 2022-07-12 with a primary completion date of 2025-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a first in human, Phase 1/2 open-label multi-center, dose escalation and expansion study to evaluate the safety, tolerability, PK, PD and efficacy of RNK05047 when administered an intravenous (IV) infusion to subjects with advanced solid tumors, including diffuse large B-cell lymphoma (DLBCL). This is a 2-part study (dose escalation, cohort expansion) with sequential enrollment.
Eligibility Criteria
Inclusion Criteria: * Pathologically documented locally advanced or metastatic solid tumor * Refractory or intolerant to all available standard-of-care therapies for advanced disease * Measurable disease * Archived tumor tissue collected * ECOG Performance Status of 0 or 1 * BMI ≥ 18 kg/m2 * Adequate liver, renal, hematologic, and coagulation parameters * Negative serum pregnancy test (for women of childbearing potential) at Screening and a negative urine or serum pregnancy test on Day 1 prior to the first infusion * Males and females of childbearing potential must agree to use a highly effective method of contraception during treatment and for at least 4 months after the last dose of study treatment. * Must be able to understand and comply with the conditions of the protocol and must have read and understood the consent form and provided written informed consent. Exclusion Criteria: * Concurrent anticancer therapy: Radiotherapy, chemotherapy, biological therapy, or other anticancer investigational agents NOTE: at least 5 half-lives must have been ensued for any prior systemic cancer therapy agent before subject received the study drug on Day 1 * Unresolved toxicities from prior anticancer therapy, defined as not having resolved according to CTCAE version 5.0 Grade ≤ 1, excluding Grade 1 alopecia * Presence or suspicion of active central nervous system (CNS) metastases and/or leptomeningeal carcinomatosis * Peripheral neurotoxicity ≥ Grade 2 according to CTCAE v5.0 * Known active infection with HIV, HTLV-1, hepatitis B or C * Women who are pregnant or breastfeeding * History of another malignancy unless the subject has been treated with curative intent for this malignancy
Contact & Investigator
Linda Grummer
STUDY DIRECTOR
Ranok Therapeutics
Frequently Asked Questions
Who can join the NCT05487170 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Advanced Solid Tumor. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05487170 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT05487170 currently recruiting?
Yes, NCT05487170 is actively recruiting participants. Contact the research team at lindagrummer@ranoktherapeutics.com for enrollment information.
Where is the NCT05487170 trial being conducted?
This trial is being conducted at Atlanta, United States, Louisville, United States, New York, United States, Beijing, China and 1 additional location.
Who is sponsoring the NCT05487170 clinical trial?
NCT05487170 is sponsored by Ranok Therapeutics (Hangzhou) Co., Ltd.. The principal investigator is Linda Grummer at Ranok Therapeutics. The trial plans to enroll 32 participants.