A Study of LM-24C5 For Advanced Solid Tumors
Trial Parameters
Brief Summary
To assess the safety and tolerability, obtain the recommended phase 2 dose (RP2D)/optimal biologic dose (OBD) and/or Maximum Tolerated Dose (MTD) for LM-24C5 in subjects with advanced solid tumors.
Eligibility Criteria
Inclusion Criteria: 1. Subjects who are fully informed of the purpose, nature, method and possible adverse reactions of the study, and are willing to participate in the study and sign the informed consent form (ICF) prior to any study related procedures. 2. Aged ≥18 years old when sign the ICF, male or female. 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, and no deterioration within 2 weeks prior to the first dose. 4. Life expectancy ≥ 3 months. 5. Subjects must have histological or cytological confirmation of recurrent or refractory advanced solid tumors, and have progressed on standard therapy, or are intolerable for available standard therapy, or there is no available standard therapy. 6. Formalin-fixed paraffin-embedded (FFPE) tumor tissue samples meet the minimum requirements. 7. At least one measurable lesion according to RECIST v1.1. 8. Subjects must show appropriate organ and marrow function in laboratory examinations within 7 days prior to the first d