A Study of IO Plus Radiotherapy in Patients With Advanced ESCC.
Trial Parameters
Brief Summary
This study is a single-arm, prospective, phase II trial for patients with metastatic esophageal squamous cell carcinoma (ESCC) who received immunotherapy plus chemotherapy as the first-line treatment. The aim of the study is to determine if intervening with combined local therapy and immunotherapy and chemotherapy in patients with ESCC led to significant improvements in survival and disease control compared with historical data.
Eligibility Criteria
Inclusion Criteria: 1. Age 18-80, had an Eastern Cooperative Oncology Group performance status score of 0-1; 2. Patients had unresectable or recurrent esophageal squamous cell carcinoma that precluded esophagectomy or definitive chemoradiation, or distant metastatic disease; 3. Patients had received no previous systemic therapy (patients who had progressed ≥6 months after \[neo\]adjuvant therapy or definitive chemoradiation were eligible); 4. Patients accepted at least one cycle of anti-PD-1 immunotherapy combined chemotherapy as 1st line treatment. 5. All lesions of current diagnosis did not receive local treatment such as radiotherapy, surgery, radiofrequency ablation before enrollment. 6. The measurable lesion was determined by the investigator based on the RECIST 1.1 assessment. A lesion located in a previous radiotherapy area can be considered a target lesion if it is confirmed to progress and is considered to be measurable according to RECIST 1.1. 7. Estimated survival time \>12