A Single-Center, Single-Arm Study of Neoadjuvant Short-Course Radiotherapy With IL-2 Followed by Sequential Immunotherapy With CAPOX Combined With PD-1 Antibody and IL-2 for Locally Advanced Rectal Cancer
Trial Parameters
Brief Summary
A Single-Center, Single-Arm Study of Neoadjuvant Short-Course Radiotherapy with IL-2 Followed by Sequential Immunotherapy with CAPOX Combined with PD-1 antibody and IL-2 for Locally Advanced Rectal Cancer
Eligibility Criteria
Inclusion Criteria: * Males and females aged between 18 and 70 years; * ECOG (Eastern Cooperative Oncology Group) performance status score of 0 or 1; * Tumor tissue samples obtained and histologically confirmed as rectal adenocarcinoma; * Adequate hematological, liver, and kidney functions: neutrophil count ≥ 1.5×10\^9/L; platelet count ≥ 75×10\^9/L; serum total bilirubin ≤ 1.5× upper limit of normal (UNL); aspartate aminotransferase ≤ 2.5× UNL; alanine aminotransferase ≤ 2.5× UNL; serum creatinine ≤ 1.5× UNL. Exclusion Criteria: * Metastatic disease (Stage IV); * Recurrent rectal cancer; * Concurrent active bleeding, perforation, or other complex situations that cannot be addressed with emergency colostomy surgery alone; * Previous systemic anti-cancer treatment for colorectal cancer; * Coexistence of other non-colorectal cancer malignancies; * Patients with any active autoimmune diseases, or a history of needing steroids or immunosuppressive drugs; * Patients with interstitial lung d