NCT06053099 A Prospective Cohort Study to Evaluate Molecular pRognostic Factors and Resistance Mechanisms to Osimertinib in Adjuvant Treatment of Completely Resected pIB-IIIA Non-small Cell Lung Carcinoma With Common EGFR Mutations (L858R and Del19)
| NCT ID | NCT06053099 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Intergroupe Francophone de Cancerologie Thoracique |
| Condition | Non Small Cell Lung Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 300 participants |
| Start Date | 2024-01-22 |
| Primary Completion | 2031-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 300 participants in total. It began in 2024-01-22 with a primary completion date of 2031-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
IFCT-2202 ROSIE study aims to incorporate a broad-panel centralized NGS testing at baseline in all patients with completely resected NSCLC with common EGFR mutation after confirmation of an optimal preoperative extension assessment and with a centralized review of the quality of the surgical excision. Furthermore, the IFCT-2202 ROSIE study also aims to study the molecular events associated with relapse on, or after osimertinib exposure, that should result in the opportunity to accede to optimal treatment in case of metastatic relapse.
Eligibility Criteria
Inclusion Criteria: 1. Signed Informed consent. 2. Age ≥ 18 years. 3. Pre-surgical disease evaluation including brain MRI/CT-scan and total body PET-FDG CT-scan prior to surgery. 4. Histologically complete anatomical resection (R0) of stage pIB-IIIA (pTNM 8th edition) NSCLC. 5. Presence of a common EGFR mutation (Del19 or L858R). 6. Archival tumour tissue FFPE blocks from surgery available for centrally molecular analyses. 7. Patient eligible to receive osimertinib adjuvant therapy in a 3-year intent to treat decision; patients could receive if necessary adjuvant chemotherapy before starting osimertinib treatment. 8. Patient who is capable, according to the investigator, of complying with the study's requirements and restrictions. 9. Patient followed in the institution on a regular basis (every 3 to 6 months) according to standard recommendations. 10. Estimated life expectancy \> 3 years. 11. Woman patients who are of childbearing potential are eligible: * They must have a negative pregnancy test before the first dose of osimertinib. * They must agree to use effective methods of contraception throughout the course of treatment and should be maintained for 2 months after the end of treatment. 12. Male subjects who are sexually active with a woman of childbearing potential are eligible if an efficacious contraception method should be used during the treatment and during the 4 months following the last dose. Exclusion Criteria: 1. History of cancer, except for the following situations: Patients with history of cancer for more than 3 years are eligible if they have been treated and considered cured. Patients with history of in situ carcinoma of the cervix or non-melanoma skin carcinoma are eligible. 2. Neoadjuvant anti-cancer treatment (osimertinib and/or chemotherapy or other anti-cancer treatment). 3. Incompletely resected NSCLC (R1 or R2). 4. Any medical condition that would, according to the investigator's judgment, prevent the patient's participation in the clinical study. 5. Active infection (e.g. patients receiving treatment for infection) including hepatitis C virus (HCV) and human immunodeficiency virus (HIV), or active uncontrolled hepatitis B infection except for the situations described in APPENDIX I. Screening for chronic conditions is not required.
Frequently Asked Questions
Who can join the NCT06053099 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Non Small Cell Lung Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06053099 currently recruiting?
Yes, NCT06053099 is actively recruiting participants. Visit ClinicalTrials.gov or contact Intergroupe Francophone de Cancerologie Thoracique to inquire about joining.
Where is the NCT06053099 trial being conducted?
This trial is being conducted at Angers, France, Bayonne, France, Boulogne, France, Bron, France and 11 additional locations.
Who is sponsoring the NCT06053099 clinical trial?
NCT06053099 is sponsored by Intergroupe Francophone de Cancerologie Thoracique. The trial plans to enroll 300 participants.
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