A Prospective Cluster-Randomized, Controlled Crossover Trial to Validate an Electronic "Resistance Calculator"
Trial Parameters
Brief Summary
Primary objective: \- Our aim is to validate the "Shamir Resistance Calculator" in a prospective crossover trial, in order to shorten the time to initiation of appropriate antimicrobials among hospitalized septic patients. Secondary objectives: \- To evaluate the impact of using the "Shamir Resistance Calculator" with regards to: * new acquisitions of multi-drug resistant organisms (MDRO) * the empiric usage of broad-spectrum agents (e.g., carbapenems, vancomycin) * acute Clostridiodes difficile infections * In-hospital mortality.
Eligibility Criteria
Inclusion Criteria: * Adult patients (age\>18 years) * Patients who are hospitalized at Shamir MC or at Hadassah Medical Organization during the study period. o Patients admitted to the ER and later-on discharged home, or discharged from the ER to a different facility, will be excluded as it will not enable us to follow all the designated outcomes. * Patients for which antibiotic treatment was initiated, empirically, due to acute sepsis. * Patients for which antibiotics were initiated as part of a main-consolidative regimen, or as part of a pre-emptive regimen, will not be included in the study. * Sepsis will be defined in accordance to established criteria1. Exclusion Criteria: \-