NCT07118072 A Pilot Study to Examine the Efficacy of Internet-Delivered Skills Training in Affective and Interpersonal Regulation (i-STAIR) for Individuals With Adverse Childhood Experiences and Subsyndromal Depression
| NCT ID | NCT07118072 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Institute of Mental Health, Singapore |
| Condition | Subthreshold Depression |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2025-10-31 |
| Primary Completion | 2028-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 150 participants in total. It began in 2025-10-31 with a primary completion date of 2028-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The present study aims to pilot internet-delivered Skills Training in Affective and Interpersonal Regulation (i-STAIR) as a transdiagnostic emotion dysregulation intervention to prevent progression to depression in individuals with adverse childhood experiences (ACEs) and subsyndromal depression. The aims of the study are: (i) to examine the effectiveness of i-STAIR on emotion dysregulation, interpersonal skills, depressive and PTSD symptoms at post-intervention i.e. on completion of the intervention (8 weeks); (ii) to examine if gains were maintained at 3 month post- intervention follow-up.
Eligibility Criteria
Inclusion Criteria: * Exposed to mild, moderate or severe adverse childhood experiences (ACEs) * Screened positive for subsyndromal depression * Singapore citizens or permanent residents (PRs) * Aged 21 years to 65 years * Able to speak and understand English * Willing and able to undergo intervention and assessment online Exclusion Criteria: * Currently diagnosed with any mental disorder diagnoses; * Experience cognitive impairment as determined by attending physician * Have received or currently receiving dialectical behavior therapy (DBT) due to similarities with i-STAIR * Female participants who are pregnant
Contact & Investigator
Mythily Subramaniam, MBBS, Ph.D.
STUDY DIRECTOR
Institute of Mental Health, Singapore
Frequently Asked Questions
Who can join the NCT07118072 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, up to 65 Years, studying Subthreshold Depression. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07118072 currently recruiting?
Yes, NCT07118072 is actively recruiting participants. Contact the research team at imhresearch@imh.com.sg for enrollment information.
Where is the NCT07118072 trial being conducted?
This trial is being conducted at Singapore, Singapore.
Who is sponsoring the NCT07118072 clinical trial?
NCT07118072 is sponsored by Institute of Mental Health, Singapore. The principal investigator is Mythily Subramaniam, MBBS, Ph.D. at Institute of Mental Health, Singapore. The trial plans to enroll 150 participants.
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