NCT07310784 A Phase II Trial of LM103 in Advanced Melanoma
| NCT ID | NCT07310784 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | Suzhou BlueHorse Therapeutics Co., Ltd. |
| Condition | Advanced Melanoma |
| Study Type | INTERVENTIONAL |
| Enrollment | 92 participants |
| Start Date | 2025-12-16 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 92 participants in total. It began in 2025-12-16 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
A total of 92 subjects with advanced melanoma who met the inclusion criteria will be randomly assigned in a 1:1 ratio to the experimental group and the control group in this phase II trial. The study will be followed up until 24 months after treatment.
Eligibility Criteria
Inclusion Criteria: * At the date of signing Informed Consent Form (ICF), 18 \~75 years old, male or female; * Expected survival time \>3 months; * ECOG performance status 0-1; * Patients with unresectable recurrent/metastatic melanoma (excluding uveal melanoma) who have failed at least two lines of standard treatment: • Patients need to have failed or be intolerant to PD-1 antibody treatment; • If the BRAF V600 mutation is positive, treatment with BRAF±MEK inhibitors must fail; • If the NRAS mutation is positive, treatment with Tunlametinib must fail; * Patients have lesions that can be used for surgical resection or biopsy puncture; * Even after tumor tissue resection/biopsy puncture, there should still be at least one measurable lesion (according to RECIST1.1); * Patients have sufficient hematology and organ functions; * Voluntarily sign a written informed consent form (ICF). Exclusion Criteria: * A history of other malignant tumors within the past 5 years, excluding malignant tumors that can be expected to heal after treatment (including but not limited to well-treated thyroid cancer, cervical carcinoma in situ, basal or squamous cell skin cancer, or ductal carcinoma in situ of the breast treated by radical surgery); * Adverse reactions caused by previous treatments have not been recovered to grade ≤1(CTCAE V5.0) (excluding the laboratory tests from the inclusion criteria, alopecia and neurotoxicity, and hypothyroidism, adrenal insufficiency and hypopituitarism that cannot be restored to grade 2 as determined by the investigators for a long time); * Any immune-related adverse reaction (irAE) with a severity level greater than grade 3 that has occurred during any previous immunotherapy and has been permanently discontinued; * Have received vaccination within two months prior to tumor tissue procurement surgery, or plan to receive vaccination during the study; * Have received TIL cell therapy, allogeneic T cell therapy or NK cell therapy within 6 months prior to signing the ICF; * Have received allogeneic hematopoietic stem cell transplantation or solid organ transplantation in the past; * Suffering from central nervous system metastases and/or cancerous meningitis. Patients who have received brain metastasis treatment and whose conditions have been stable for at least 6 months, and there is no evidence of new or expanded brain metastases may consider participating in this study; * Suffering from or suspected of having an active autoimmune disease; * Suffering from a large amount of pleural effusion or ascites with clinical symptoms or requiring symptomatic treatment; * Patients with current or previous irreversible interstitial lung disease; * Suffering from serious cardiovascular and cerebrovascular diseases; * Suffering from an active infection that requires systemic treatment; * Suffering from infectious diseases such as hepatitis B, hepatitis C, syphilis, AIDS; * Patients with esophageal or gastric varices requiring immediate intervention (such as ligation or sclerotherapy), or those with a higher risk of bleeding as recommended by the investigator or gastroenterologist or hepatologist, evidence of portal hypertension (including splenomegaly found in imaging examinations), or a history of variceal bleeding must undergo endoscopic assessment within 3 months before enrollment; * Uncontrolled metabolic disorders, such as diabetes, or other non-malignant organ or systemic diseases or secondary reactions to cancer, can lead to higher medical risks and/or uncertainties in survival assessment; * Those who are known to be allergic to any component of the investigational drug and the LM103 product formula; * Women who are pregnant or breastfeeding; * As determined by the investigators, there are other severe, acute or chronic medical diseases, mental disorders or laboratory abnormalities that may increase the risks related to participation in the study or may interfere with the interpretation of the study results.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07310784 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Advanced Melanoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07310784 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT07310784 currently recruiting?
Yes, NCT07310784 is actively recruiting participants. Contact the research team at guoj307@126.com for enrollment information.
Where is the NCT07310784 trial being conducted?
This trial is being conducted at Beijing, China, Fuzhou, China, Guangzhou, China, Nanning, China and 9 additional locations.
Who is sponsoring the NCT07310784 clinical trial?
NCT07310784 is sponsored by Suzhou BlueHorse Therapeutics Co., Ltd.. The trial plans to enroll 92 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.