A Phase 1 Study of IM-1021 in Participants With Advanced Cancer
Trial Parameters
Brief Summary
IM-1021-101 is a Phase 1 study to determine the safety and effectiveness of IM-1021 in treating participants with advanced cancer.
Eligibility Criteria
Inclusion Criteria: 1. Informed consent signed by the participant prior to conducting study-specific procedures 2. ≥18 years of age 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 4. Histological or cytological diagnosis of: Part A: advanced B-cell lymphomas or solid tumors, of the following subtypes: B-cell Lymphomas: * Mantle cell lymphoma (MCL) * Diffuse large B-cell lymphoma (DLBCL) (including Richter's transformation) * Follicular lymphoma * Small lymphocytic lymphoma (SLL) Solid Tumors: * Pancreatic cancer * Non-squamous non-small cell lung cancer (NSCLC) * Malignant mesothelioma * Epithelial ovarian cancer. Participants with fallopian tube and/or peritoneal malignancies are also eligible. * Triple-negative breast cancer. * Liposarcoma Other, unlisted histologies, if approved by the Sponsor Medical Monitor Part B Cohorts B1, B2, and B3: Histological or cytological diagnosis of the cohort-specific disease indication. Indications may include those list