A Clinical Study to Evaluate the Safety and Tolerability of AWT020 in Patients With Advanced Malignancies
Trial Parameters
Brief Summary
The purpose of this phase I clinical study was to evaluate the safety and tolerability of AWT020 monotherapy and combination with other antitumor therapies in patients with advanced malignancies
Eligibility Criteria
Inclusion Criteria: 1. Both male and female subjects who are at least 18 years old at the time of signing the consent form; 2. Inclusion of patients with advanced malignancies confirmed histologically or cytologically and meeting the following requirements: * Single-agent dose escalation and expansion phase to include patients with advanced malignant tumors who have failed or are intolerant of standard treatment, or have no standard treatment options; * Therapeutic effect expansion stage of single drug: 1. NSCLC: histologically or cytologically confirmed, unresectable locally advanced, relapsed, or distant metastatic NSCLC that has progressed after prior treatment with PD-(L)1 antibody and platinum-containing chemotherapy (except after the last dose \> Progression of adjuvant and neoadjuvant therapy within 6 months). Subjects with EGFR or ALK mutations will need to progress with prior treatment with appropriate kinase inhibitors. 2. Melanoma: histologically unresectable stage III or