A Clinical Study on Neoadjuvant Treatment of Resectable Head and Neck Squamous Carcinoma With Immune-targeted Therapy and Lysogenic HSV Virus
This study tests a new combination treatment given before surgery for head and neck cancer. The treatment combines immune-boosting therapy with a modified virus designed to fight cancer cells.
Key Objective:This trial is testing whether combining immune therapy with a lysogenic HSV virus can safely shrink head and neck cancers before surgery.
Who to Consider:Patients with surgically resectable squamous cell carcinoma of the head and neck who are willing to receive experimental treatment before surgery should consider this trial.
Trial Parameters
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
Brief Summary
Evaluation of the safety and tolerability of immune-targeted therapy combined with neoadjuvant therapy with lysogenic HSV virus for patients with surgically resectable squamous carcinoma of the head and neck.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥18 and ≤70 years old, regardless of gender; 2. Patients with head and neck squamous carcinoma who are pathologically confirmed and fulfill the following conditions: 1. Patients with locally advanced head and neck squamous carcinoma (excluding nasopharyngeal, salivary gland and thyroid malignant tumors) who are initially diagnosed and have no distant metastasis; * Non oropharyngeal HNSCC carcinoma and HPV-negative oropharyngeal carcinoma, stages III, IVA and IVB; * HPV-positive oropharyngeal cancers, stages II and III; * HPV status of oropharyngeal cancer will be determined by p16 immunohistochemistry. 2. Treatable by surgical resection as evaluated by head and neck surgery; 3. Definite lymph node metastasis and lymph node stage is not N0 or Nx. 3. An Eastern Cooperative Oncology Group (ECOG) physical status score of 0 to 1; 4. Have adequate organ and bone marrow function as defined below: 5. Subjects voluntarily enrolled in the study, signed an informed cons