18F-FSPG PET in Imaging Patients With Liver Cancer Before Undergoing Surgery or Transplant
Trial Parameters
Brief Summary
This clinical trial studies fluorine F 18 L-glutamate derivative BAY94-9392 (18F-FSPG) positron emission tomography (PET) in imaging patients with liver cancer before undergoing surgery or transplant. Diagnostic procedures, such as 18F-FSPG PET, may help find and diagnose liver cancer and find out how far the disease has spread.
Eligibility Criteria
Inclusion Criteria: 1. Diagnosis of HCC with one or more of the following: 1. Liver mass with non-rim arterial phase hyperenhancement (APHE) and one of the following: 1) 10-19 mm with ≥2 additional major features according to LI-RADS criteria ("washout", enhancing "capsule", and/or threshold growth), 2) 10-19 mm with "washout" and visibility at antecedent ultrasound (US) but with no "capsule" or threshold growth, 3) 10-19 mm with ≥50% size increase in ≤6 months but with no "washout" or "capsule" or 4) ≥20 mm with ≥1 additional major feature according to LI-RADS criteria ("washout", enhancing "capsule", or threshold growth). 2. Lesions that meet LI-RADS 4 criteria or 3. Lesions that meet LI-RADS 5 criteria or 4. Suggestive imaging findings plus AFP \> 200 mg/dL or 5. Tumor confirmed by arteriography or 6. Pathologic confirmation of tumor or 2. Diagnosis of a benign abdominal or pelvic tumor with the following characteristics: 1. Liver mass (≥ 1 cm) that has suggestive imaging findings o