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sickle cell disease Clinical Trials in United States

Active clinical trials for sickle cell disease with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.

Active Trials: 20 // Recruiting: 20 Phases: Phase 1, Phase 1, Phase 2 // Updated: Daily
Total Trials
20
Recruiting Now
20
Country
🇺🇸 United States

Active Trials in United States (20)

NCT07083531
Recruiting

Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait

Enrollment
50 pts
Country
🇺🇸 United States
UConn Health
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NCT07392216
Recruiting

Functional Ovarian Reserve in Sickle Cell Disease

Enrollment
440 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
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NCT07674277
Recruiting

Virtual Reality for SCD VOC

Enrollment
50 pts
Country
🇺🇸 United States
University of Maryland, Baltimore
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NCT01245179 Phase 1
Recruiting

Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease

Enrollment
18 pts
Country
🇺🇸 United States
Abdullah Kutlar
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NCT04398628
Recruiting

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

Enrollment
3,000 pts
Country
🇺🇸 United States
American Thrombosis and Hemostasis ...
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NCT07226219 Phase 1
Recruiting

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

Enrollment
72 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
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NCT05377372
Recruiting

Early Life Exposures Among Children With Sickle Cell Disease

Enrollment
20 pts
Country
🇺🇸 United States
University of Alabama at Birmingham
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NCT06477289
Recruiting

Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease

Enrollment
65 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
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NCT04055818 Phase 1
Recruiting

A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

Enrollment
20 pts
Country
🇺🇸 United States
EpiDestiny, Inc.
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NCT07252050 Phase 1, Phase 2
Recruiting

Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease

Enrollment
24 pts
Country
🇺🇸 United States
Arkansas Children's Hospital Resear...
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NCT02447874 Phase 1, Phase 2
Recruiting

Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease

Enrollment
21 pts
Country
🇺🇸 United States
Emory University
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NCT05431088 Phase 2, Phase 3
Recruiting

A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

Enrollment
389 pts
Country
🇺🇸 United States
Pfizer
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NCT06930703 Phase 1, Phase 2
Recruiting

Cannabidiol in Sickle Cell Disease

Enrollment
52 pts
Country
🇺🇸 United States
Icahn School of Medicine at Mount S...
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NCT06506461 Phase 1
Recruiting

Gene Editing For Sickle Cell Disease

Enrollment
25 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
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NCT06555939
Recruiting

Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease

Enrollment
25 pts
Country
🇺🇸 United States
Boston Children's Hospital
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NCT07090668
Recruiting

Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease

Enrollment
20 pts
Country
🇺🇸 United States
Emory University
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NCT06635902 Phase 2
Recruiting

Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease

Enrollment
99 pts
Country
🇺🇸 United States
Suvankar Majumdar
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NCT06442761 Phase 1
Recruiting

SCD Stem Cell Mobilization and Apheresis Using Motixafortide

Enrollment
20 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
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NCT04774536 Phase 1, Phase 2
Recruiting

Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease

Enrollment
9 pts
Country
🇺🇸 United States
Mark Walters, MD
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NCT06944067
Recruiting

Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

Enrollment
50 pts
Country
🇺🇸 United States
National Human Genome Research Inst...
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Frequently Asked Questions

How many sickle cell disease clinical trials are active in United States?
There are currently 20 active clinical trials for sickle cell disease with sites in United States, of which 20 are actively recruiting patients.
How can I join a sickle cell disease clinical trial in United States?
To join a sickle cell disease clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.
What phases are sickle cell disease trials in United States?
Active sickle cell disease trials in United States span Phase 1, Phase 1, Phase 2, Phase 2, Phase 3, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.
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All United States Trials → Global sickle cell disease Trials → All Countries → All Trials →
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology