🇺🇸 United States Country × Condition
sickle cell disease Clinical Trials in United States
Active clinical trials for sickle cell disease with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.
Active Trials: 20 // Recruiting: 20 Phases: Phase 1, Phase 1, Phase 2 // Updated: Daily
Total Trials
20
Recruiting Now
20
Country
🇺🇸 United States
Active Trials in United States (20)
NCT07083531
Recruiting
Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
Enrollment
50 pts
Country
🇺🇸 United States
UConn Health
View Trial → NCT07392216
Recruiting
Functional Ovarian Reserve in Sickle Cell Disease
Enrollment
440 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
View Trial → NCT07674277
Recruiting
Virtual Reality for SCD VOC
Enrollment
50 pts
Country
🇺🇸 United States
University of Maryland, Baltimore
View Trial → NCT01245179 Phase 1
Recruiting
Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease
Enrollment
18 pts
Country
🇺🇸 United States
Abdullah Kutlar
View Trial → NCT04398628
Recruiting
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
Enrollment
3,000 pts
Country
🇺🇸 United States
American Thrombosis and Hemostasis ...
View Trial → NCT07226219 Phase 1
Recruiting
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
Enrollment
72 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
View Trial → NCT05377372
Recruiting
Early Life Exposures Among Children With Sickle Cell Disease
Enrollment
20 pts
Country
🇺🇸 United States
University of Alabama at Birmingham
View Trial → NCT06477289
Recruiting
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease
Enrollment
65 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
View Trial → NCT04055818 Phase 1
Recruiting
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
Enrollment
20 pts
Country
🇺🇸 United States
EpiDestiny, Inc.
View Trial → NCT07252050 Phase 1, Phase 2
Recruiting
Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
Enrollment
24 pts
Country
🇺🇸 United States
Arkansas Children's Hospital Resear...
View Trial → NCT02447874 Phase 1, Phase 2
Recruiting
Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease
Enrollment
21 pts
Country
🇺🇸 United States
Emory University
View Trial → NCT05431088 Phase 2, Phase 3
Recruiting
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Enrollment
389 pts
Country
🇺🇸 United States
Pfizer
View Trial → NCT06930703 Phase 1, Phase 2
Recruiting
Cannabidiol in Sickle Cell Disease
Enrollment
52 pts
Country
🇺🇸 United States
Icahn School of Medicine at Mount S...
View Trial → NCT06506461 Phase 1
Recruiting
Gene Editing For Sickle Cell Disease
Enrollment
25 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
View Trial → NCT06555939
Recruiting
Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease
Enrollment
25 pts
Country
🇺🇸 United States
Boston Children's Hospital
View Trial → NCT07090668
Recruiting
Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease
Enrollment
20 pts
Country
🇺🇸 United States
Emory University
View Trial → NCT06635902 Phase 2
Recruiting
Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease
Enrollment
99 pts
Country
🇺🇸 United States
Suvankar Majumdar
View Trial → NCT06442761 Phase 1
Recruiting
SCD Stem Cell Mobilization and Apheresis Using Motixafortide
Enrollment
20 pts
Country
🇺🇸 United States
St. Jude Children's Research Hospit...
View Trial → NCT04774536 Phase 1, Phase 2
Recruiting
Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
Enrollment
9 pts
Country
🇺🇸 United States
Mark Walters, MD
View Trial → NCT06944067
Recruiting
Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
Enrollment
50 pts
Country
🇺🇸 United States
National Human Genome Research Inst...
View Trial → Frequently Asked Questions
How many sickle cell disease clinical trials are active in United States?
There are currently 20 active clinical trials for sickle cell disease with sites in United States, of which 20 are actively recruiting patients.
How can I join a sickle cell disease clinical trial in United States?
To join a sickle cell disease clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.
What phases are sickle cell disease trials in United States?
Active sickle cell disease trials in United States span Phase 1, Phase 1, Phase 2, Phase 2, Phase 3, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology