To join a prostate cancer clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are prostate cancer trials in United States?

Active prostate cancer trials in United States span Phase 1, Phase 2, Phase 1, Phase 2, Phase 4, Phase 3, EARLY_Phase 1, Phase 2, Phase 3. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology

Active Trials in United States (44)

Stem Cells for Erectile Dysfunction Post RALP

The Florida ASCENT Study

Study of JANX014 in Subjects With Metastatic Castration-Resistant Prostate Cancer

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

Phase I Study of 225Ac-J591 Plus 177Lu-PSMA Small Molecule for Progressive Metastatic Castration Resistant Prostate Cancer

FK-PC101 as Adjuvant Therapy for Men With High-Risk Prostate Cancer

PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.

Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer

Circulating Tumor Cell Analysis in Patients With Localized Prostate Cancer Undergoing Prostatectomy

ASCVD Management Using CCTA in Prostate Cancer Patients on ADT

Fusion or Cognitive Ultrasound-guided Biopsy to Detect Prostate Cancer

Utilization of Educational Interventions in Completion of Genetic Testing in Black Patients With High-Risk Prostate Cancer

Transrectal Ultrasound Robot-Assisted Prostate Biopsy

177Lu-PSMA-617 With Liver Directed Therapy in Metastatic Castration Resistant Prostate Cancer

A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer

The SUGAR Study; SBRT and Relugolix) for Prostate Cancer

PSMA-Directed Para-Aortic Radiation Therapy for Oligorecurrent Prostate Cancer

Virtual Reality Headset and/or Aromatherapy for Patients Undergoing a Transperineal Prostate Biopsy

Understanding of Genetics by Men at Risk for Prostate Cancer

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

A Study to Determine the Preferred Dose of the Drug, Lisinopril, for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer

HoLEP Prior to Radiation Therapy for Patients With LUTS/Retention and Concurrent Prostate Cancer

Barrigel® PPRT (Post-Prostatectomy Radiation Therapy) Trial

A Study to Learn About Heart-Related Risks in Elderly Men With Advanced Prostate Cancer Treated With Enzalutamide or Darolutamide

Feasibility of Timesaving When Using Histolog Confocal Laser Endomicroscopy for Margin Assessment in Prostatectomy Specimen

Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer

A Ph Ib Study of REGN5678 Plus Cemiplimab in Patients With mCRPC

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Single-Port Transvesical Partial Prostatectomy Versus High Intensity Focused Ultrasound

Using a mHealth App to Improve Quality-of-Life Outcomes in Black Prostate Cancer Survivors

Neoadjuvant ADT + Darolutamide With Pembrolizumab, Followed by Adjuvant Pembrolizumab in Molecularly Stratified High-Risk Prostate Cancer

Navigator-Assisted Hypofractionation (NAVAH) on Radiation Therapy Completion in Breast Cancer and Prostate Cancer

PSMA-PET Imaging for Detecting Early Metastatic Prostate Cancer in Men w/ High Decipher Test Scores

Androgen-responsive POSLUMA-guided Intra-prostatic Boost

FOG-001 in Locally Advanced or Metastatic Solid Tumors

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

Prostate Tissue BioBank

SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

A Feasibility Study of Biometric Measurements Via Wearable Smart Watch Technology for Evaluation of Vasomotor Symptoms in Patients Treated With Androgen Deprivation Therapy for Prostate Cancer (Prostate 007)

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