To join a prostate cancer clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are prostate cancer trials in United States?

Active prostate cancer trials in United States span Phase 4, Phase 2, Phase 2, Phase 3, Phase 1, Phase 2, Phase 3, Phase 1, EARLY_Phase 1. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology

Active Trials in United States (46)

Impact of Fluciclovine (18F) PET (Positron Emission Tomography) on the Management of Prostate Cancer Following Negative or Equivocal PSMA (Prostate-Specific Membrane Antigen) PET Imaging at the Time of Biochemical Recurrence

Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer

Using MRI to Identify Areas to Receive Lower Doses of Radiation Treatment in Men With Prostate Cancerdose Mapping to Preserve Quality of Life

Older Men's Decision Making About Active Surveillance for Prostate Cancer - Aim 3: Decision Aid Efficacy Testing

Real World Prostate Cancer Registry

4-aminopyridine Treatment for Nerve Injury

TRANBERG® Transperineal MR/US Fusion Laser--Induced Thermal Therapy for Men With Prostate Cancer

Pembro With Radiation With or Without Olaparib

SBRT Boost for Unfavorable Prostate Cancer'

Diffusion Basis Spectrum Imaging of the Prostate

MATCH-UP: MAking Telehealth-Delivery of Cancer Care at Home Effective and Safe-Upscaled: A Pragmatic Cluster Randomized Trial

The SUGAR Study; SBRT and Relugolix) for Prostate Cancer

Axelopran for Advanced Cancer in Patients Receiving Opioids

Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery

A Single-Arm, Blinded, Fluorescent PSMA Histopathology Trial of AS1986NS

Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue

Vascular Optimized Radiotherapy Tuned to Critical Structures for Erectile Function Using High-Precision X-Ray Treatment

Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort

ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer

Using a mHealth App to Improve Quality-of-Life Outcomes in Black Prostate Cancer Survivors

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

Connect2Care: Prostate Cancer Education and Screenings for African American Men

Single-Port Transvesical Partial Prostatectomy Versus High Intensity Focused Ultrasound

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

SAFE Nerve Sparing Guided by Micro-ultrasound (MUS)

A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer

Utilization of Educational Interventions in Completion of Genetic Testing in Black Patients With High-Risk Prostate Cancer

Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy

Barrigel® PPRT (Post-Prostatectomy Radiation Therapy) Trial

Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy

Prospective Database of Clinical Outcomes Following Cryotherapy for Ablation of Clinically Localized Prostate Cancer

Enzalutamide and PDS01ADC in PET Positive Recurrent Prostate Cancer (pprPC) Without Testosterone Lowering Therapy

Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types

MRI Risk Maps for Prostate Cancer Diagnosis Using Targeted Biopsy

Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer

Cleveland African American Prostate Cancer Project

MRI-based Focal Intraprostatic Simultaneous Integrated Boost (SIB) Intensification With De-escalated Adaptive-risk SBRT for Patients With Low to Intermediate Risk Prostate Cancer

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

Outcomes of Focal Ablation for Prostate Cancer

RCT of NLP-Based Feedback for Improving SDM in Men With Localized Prostate Cancer

A Study to Determine the Preferred Dose of the Drug, Lisinopril, for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer

IDOV-Immune for Advanced Solid Tumors

Assessing Efficacy of Neoadjuvant ADT in Localized High-Risk Prostate Cancer Patients Utilizing 18F-Flotufolastat PSMA PET/CT

A Single-arm, Multicenter Prospective Study to Evaluate the Diagnostic Performance of PROSTest in Men With PSA ≥ 3ng/ml Using Biopsy as the Sole Ground Truth

Performance of Inherited Risk Assessment for Predicting Prostate Cancer From Prostate Biopsy

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