To join a prostate cancer clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are prostate cancer trials in United States?

Active prostate cancer trials in United States span Phase 1, Phase 2, Phase 2, Phase 1, EARLY_Phase 1, Phase 4, Phase 3, Phase 2, Phase 3. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology

Active Trials in United States (49)

Fusion or Cognitive Ultrasound-guided Biopsy to Detect Prostate Cancer

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Stereotactic Magnetic Resonance Guided Radiation Therapy

DESTINY-PANTUMOUR04

A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer

A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

HER2 FPBMC in Patients With Metastatic Breast and Prostate Cancer (AM006)

Hypofractionated WPPT With HDR Boost

Building on Trust: Navigating Preventive Lung, Breast, and Prostate Cancer Screenings at Community Resource Spots

Microendoscopic EI Sensing for Real-time Intraoperative Surgical Margin Assessment

A Phase 1 Study of BPX-601 CAR T-Cell Therapy in Adult Participants With Prostate Cancer That Has Returned, is Resistant to Treatment and Has Spread

Navigator-Assisted Hypofractionation (NAVAH) on Radiation Therapy Completion in Breast Cancer and Prostate Cancer

Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection

Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types

Patient Navigation Program to Improve Clinical Trial Enrollment in Cancer Patients

Circulating Tumor DNA in High Risk Localized Prostate Cancer

Serial MRI Scans During Radiation Therapy

Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

Older Men's Decision Making About Active Surveillance for Prostate Cancer - Aim 3: Decision Aid Efficacy Testing

Interstitial Assessment of Architectural Heterogeneity in Prostate Cancer Using a Fine Needle Photoacoustic Probe

Focal Therapy for Localized Prostate Cancer

The Florida ASCENT Study

Sacral Neuromodulation for Male Overactive Bladder (MOAB)

Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer

TERPS Trial for de Novo Oligometastic Prostate Cancer

CUIMC Focal Therapy Registry

Enzalutamide and PDS01ADC in PET Positive Recurrent Prostate Cancer (pprPC) Without Testosterone Lowering Therapy

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

Post-prostatectomy Radiation Therapy--Moderate Versus Ultra-hypofractionated (Also Known as Stereotactic Body Radiation Therapy [SBRT])

A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer

Metabolic Impact and Compliance of Controlled, Varying, Mediterranean Diets in Pre-Surgical Prostate Cancer Populations (PROVISIONS)

Study of STM-416p Administered to Patients Undergoing Radical Prostatectomy

Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance

Helping Men Adhere to Sexual Rehabilitation Following Prostate Cancer Surgery

Neoadjuvant Pembrolizumab Plus Androgen Axis Blockade Prior to Prostatectomy for High Risk Localized Prostate Cancer

Axelopran for Advanced Cancer in Patients Receiving Opioids

Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

Locally Ablative TherapY in Oligo-ProgressiVe GEnitourinary TumoRs (LAYOVER)

International Registry for Men With Advanced Prostate Cancer (IRONMAN)

RCT of NLP-Based Feedback for Improving SDM in Men With Localized Prostate Cancer

Phase II Non-Randomized Study Evaluating POSLUMA-PSMA PET Response After Oligo- Metastatic/Progressive-directed Treatment With Radiotherapy (PROMPT-R)

MATCH-UP: MAking Telehealth-Delivery of Cancer Care at Home Effective and Safe-Upscaled: A Pragmatic Cluster Randomized Trial

The SUGAR Study; SBRT and Relugolix) for Prostate Cancer

Prostate Assessment with Restriction Spectrum Imaging (RSI) MRI

Multimodal Telerehabilitation of Rural Patients With Advanced Prostate Cancer

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