🇺🇸 United States Country × Condition
heart failure Clinical Trials in United States
Active clinical trials for heart failure with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.
Active Trials: 27 // Recruiting: 27 Phases: Phase 2, Phase 3 // Updated: Daily
Total Trials
27
Recruiting Now
27
Country
🇺🇸 United States
Active Trials in United States (27)
NCT04305717
Recruiting
Use of ReDS Technology in Patients With Acute Heart Failure
Enrollment
240 pts
Country
🇺🇸 United States
Icahn School of Medicine at Mount S...
View Trial → NCT06979362 Phase 2
Recruiting
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Enrollment
200 pts
Country
🇺🇸 United States
Novo Nordisk A/S
View Trial → NCT06699056
Recruiting
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
Enrollment
2,000 pts
Country
🇺🇸 United States
Peerbridge Health, Inc
View Trial → NCT06118983
Recruiting
Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)
Enrollment
1,094 pts
Country
🇺🇸 United States
Weill Medical College of Cornell Un...
View Trial → NCT06593314
Recruiting
Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes
Enrollment
800 pts
Country
🇺🇸 United States
University of Texas Southwestern Me...
View Trial → NCT06080074 Phase 2
Recruiting
Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
Enrollment
50 pts
Country
🇺🇸 United States
Stanford University
View Trial → NCT05654272
Recruiting
Development of CIRC Technologies
Enrollment
1,000 pts
Country
🇺🇸 United States
The Cleveland Clinic
View Trial → NCT06070428
Recruiting
Project 4: ACHIEVE PATHFINDER
Enrollment
400 pts
Country
🇺🇸 United States
Henry Ford Health System
View Trial → NCT07105007
Recruiting
Proof-of-concept of a Behavioral Intervention to Improve the Cardiovascular Health of People Living With HIV
Enrollment
30 pts
Country
🇺🇸 United States
University of Washington
View Trial → NCT05972070
Recruiting
Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence
Enrollment
500 pts
Country
🇺🇸 United States
ROM Technologies, INC
View Trial → NCT06222099
Recruiting
The HEARTFELT Study
Enrollment
1,500 pts
Country
🇺🇸 United States
Heartfelt Technologies
View Trial → NCT07220798
Recruiting
Improving Self-Care of Caregivers of Adults in Homecare With Heart Failure and Cognitive Impairment
Enrollment
316 pts
Country
🇺🇸 United States
Visiting Nurse Service of New York
View Trial → NCT06174103
Recruiting
BiVACOR® Total Artificial Heart Early Feasibility Study
Enrollment
5 pts
Country
🇺🇸 United States
BiVACOR Inc.
View Trial → NCT06008197 Phase 3
Recruiting
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Enrollment
5,200 pts
Country
🇺🇸 United States
Colorado Prevention Center
View Trial → NCT04905160
Recruiting
Care Coordination to Assess Improvement in Outcomes in Hospital Readmissions
Enrollment
1,000 pts
Country
🇺🇸 United States
Aventyn, Inc.
View Trial → NCT06783335
Recruiting
Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure
Enrollment
2,150 pts
Country
🇺🇸 United States
Endotronix, Inc.
View Trial → NCT07112924
Recruiting
CCM OPEN HF Registry
Enrollment
5,500 pts
Country
🇺🇸 United States
Impulse Dynamics
View Trial → NCT05996328
Recruiting
CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)
Enrollment
1,400 pts
Country
🇺🇸 United States
VA Office of Research and Developme...
View Trial → NCT06461962
Recruiting
Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement
Enrollment
200 pts
Country
🇺🇸 United States
Oregon Health and Science Universit...
View Trial → NCT04984473
Recruiting
A Study to Evaluate Breathing Muscle Training in Cardiac Rehab
Enrollment
42 pts
Country
🇺🇸 United States
Mayo Clinic
View Trial → NCT05934487
Recruiting
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
Enrollment
1,750 pts
Country
🇺🇸 United States
Endotronix, Inc.
View Trial → NCT05873634
Recruiting
HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
Enrollment
1,000 pts
Country
🇺🇸 United States
Northwestern University
View Trial → NCT01757730
Recruiting
Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
Enrollment
1,000 pts
Country
🇺🇸 United States
Arunark Kolipaka
View Trial → NCT06364644
Recruiting
Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure
Enrollment
156 pts
Country
🇺🇸 United States
Johns Hopkins University
View Trial → NCT06271577
Recruiting
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
Enrollment
1,000 pts
Country
🇺🇸 United States
AliveCor
View Trial → NCT07650669
Recruiting
Wearable Technology in Heart Failure Patients
Enrollment
500 pts
Country
🇺🇸 United States
The Cleveland Clinic
View Trial → NCT06130059 Phase 2
Recruiting
Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation
Enrollment
60 pts
Country
🇺🇸 United States
University of Texas Southwestern Me...
View Trial → Frequently Asked Questions
How many heart failure clinical trials are active in United States?
There are currently 27 active clinical trials for heart failure with sites in United States, of which 27 are actively recruiting patients.
How can I join a heart failure clinical trial in United States?
To join a heart failure clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.
What phases are heart failure trials in United States?
Active heart failure trials in United States span Phase 2, Phase 3. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology