To join a heart failure clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are heart failure trials in United States?

Active heart failure trials in United States span Phase 4, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology

Active Trials in United States (23)

Unmitigated Aldosterone Signaling During Standard Clinical MRA Dosing

Project 2: ACHIEVE- HF

XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

A Nurse-Led Weight Monitoring Intervention For Heart Failure Quality of LIfe and Self-Care

In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation of the Inova Heart Failure Treatment Algorithm

Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients

Project 4: ACHIEVE PATHFINDER

Tailored Electronic Intervention to Improve Therapy in a Diverse Cohort of Patients With Heart Failure

UIC Multi-Ethnic DCM Registry

Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure

Study of the Progression of Chronic Cardiovascular Conditions

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

18F-mFBG Imaging for Myocardial Sympathetic Innervation

Dietary Tracking in Heart Failure

Identifying Markers of Exercise Training in Heart Failure

LVAD Conditioning for Cardiac Recovery

A Multi-center, National, Open-label, Prospective Study to Evaluate the Performance of the V-Lap™ System

PRagmatic Trial Of Messaging to Providers About Treatment of Heart Failure at Inova

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Cardiovascular Multimodality Imaging Study

HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

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