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advanced solid tumor Clinical Trials in United States

Active clinical trials for advanced solid tumor with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.

Active Trials: 21 // Recruiting: 21 Phases: Phase 1, Phase 2, Phase 1 // Updated: Daily

Total Trials

21

Recruiting Now

21

Country

🇺🇸 United States

Active Trials in United States (21)

NCT06090266 Phase 1, Phase 2

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

🇺🇸 United States

OncoResponse, Inc.

NCT06577987 Phase 1

Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies

🇺🇸 United States

NCT05873686 Phase 1

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

🇺🇸 United States

Nuvectis Pharma, Inc.

NCT05599048 Phase 1, Phase 2

Hyperpolarized 13C MRI as a Biomarker in Advanced Solid Tumors

🇺🇸 United States

Robert Bok, MD, PhD

NCT06707610 Phase 1

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK202 in Participants with Advanced Solid Tumors

🇺🇸 United States

Shanghai Allink Biotherapeutics Co....

NCT07128303 Phase 1

Study of GS-5319 in Adults With Solid Tumors

🇺🇸 United States

Gilead Sciences

NCT07197827 Phase 1, Phase 2

A Study of YL242 in Subjects With Advanced Solid Tumors

🇺🇸 United States

MediLink Therapeutics (Suzhou) Co.,...

NCT05892718 Phase 1

A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

🇺🇸 United States

FBD Biologics Limited

NCT05086692 Phase 1, Phase 2

A Beta-only IL-2 ImmunoTherapY Study

🇺🇸 United States

Medicenna Therapeutics, Inc.

NCT05269316 Phase 1, Phase 2

Study to Evaluate IMP9064 as a Monotherapy or in Combination in Patients With Advanced Solid Tumors

🇺🇸 United States

Impact Therapeutics, Inc.

NCT06132503 Phase 1

Safety, Pharmacokinetics, and Clinical Activity of LP-284 in Adult Patients With Relapsed or Refractory Lymphomas and Solid Tumors

🇺🇸 United States

Lantern Pharma Inc.

NCT06487624 Phase 1

An Engineered Sirpα Fused to Anti-Pd-L1 And Tgf-β Fusion Protein (HCB301) in Subjects With Selected Advanced Tumors

🇺🇸 United States

FBD Biologics Limited

Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions

🇺🇸 United States

University of Chicago

NCT05875168 Phase 1, Phase 2

First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors

🇺🇸 United States

NCT04585750 Phase 1, Phase 2

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

🇺🇸 United States

PMV Pharmaceuticals, Inc

NCT06233942 Phase 1

Phase 1a/1b First-in-Human Study of BG-C9074 Alone and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors

🇺🇸 United States

BeOne Medicines

NCT04999384 Phase 1

First in Human, Dose Escalation Study of AN4005

🇺🇸 United States

Adlai Nortye Biopharma Co., Ltd.

NCT06803680 Phase 1

A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors

🇺🇸 United States

BeOne Medicines

NCT04890613 Phase 1

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

🇺🇸 United States

Senhwa Biosciences, Inc.

NCT06750185 Phase 1

Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

🇺🇸 United States

NCT05768932 Phase 1

BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia

🇺🇸 United States

Frequently Asked Questions

How many advanced solid tumor clinical trials are active in United States?

There are currently 21 active clinical trials for advanced solid tumor with sites in United States, of which 21 are actively recruiting patients.

How can I join a advanced solid tumor clinical trial in United States?

To join a advanced solid tumor clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are advanced solid tumor trials in United States?

Active advanced solid tumor trials in United States span Phase 1, Phase 2, Phase 1. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology