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acute myeloid leukemia Clinical Trials in United States

Active clinical trials for acute myeloid leukemia with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.

Active Trials: 21 // Recruiting: 21 Phases: Phase 4, Phase 2 // Updated: Daily
Total Trials
21
Recruiting Now
21
Country
🇺🇸 United States

Active Trials in United States (21)

NCT06370000 Phase 4
Recruiting

Oral Azacitidine in Transplant-Eligible Patients With Acute Myeloid Leukemia (AML) Suffering From Health-Inequality

Enrollment
12 pts
Country
🇺🇸 United States
Virginia Commonwealth University
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NCT06815003 Phase 2
Recruiting

Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

Enrollment
35 pts
Country
🇺🇸 United States
City of Hope Medical Center
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NCT05672147 Phase 1
Recruiting

CD33-CAR T Cell Therapy for the Treatment of Recurrent or Refractory Acute Myeloid Leukemia

Enrollment
27 pts
Country
🇺🇸 United States
City of Hope Medical Center
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NCT07121140
Recruiting

Home Blood Transfusions

Enrollment
30 pts
Country
🇺🇸 United States
Thomas Jefferson University
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NCT06672146 Phase 2
Recruiting

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

Enrollment
93 pts
Country
🇺🇸 United States
National Cancer Institute (NCI)
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NCT06128070 Phase 2
Recruiting

Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

Enrollment
40 pts
Country
🇺🇸 United States
City of Hope Medical Center
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NCT06059391 Phase 2
Recruiting

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

Enrollment
216 pts
Country
🇺🇸 United States
City of Hope Medical Center
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NCT05564390 Phase 2
Recruiting

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Enrollment
2,000 pts
Country
🇺🇸 United States
National Cancer Institute (NCI)
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NCT03113643 Phase 1
Recruiting

SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Enrollment
72 pts
Country
🇺🇸 United States
Dana-Farber Cancer Institute
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NCT06448013 Phase 1
Recruiting

A Phase I Study Investigating the Combination of the Menin Inhibitor Ziftomenib With Venetoclax and Gemtuzumab in Pediatric Patients With Acute Myeloid Leukemia

Enrollment
22 pts
Country
🇺🇸 United States
M.D. Anderson Cancer Center
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NCT05183035 Phase 3
Recruiting

Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

Enrollment
130 pts
Country
🇺🇸 United States
PedAL BCU, LLC
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NCT04195633 Phase 2
Recruiting

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

Enrollment
60 pts
Country
🇺🇸 United States
Fred Hutchinson Cancer Center
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NCT07022678 Phase 3
Recruiting

Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

Enrollment
556 pts
Country
🇺🇸 United States
Children's Oncology Group
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NCT06892158
Recruiting

Massage Impact on Sleep in Pediatric Oncology

Enrollment
70 pts
Country
🇺🇸 United States
Children's Hospital of Philadelphia
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NCT07306832 Phase 1
Recruiting

A Study to Assess Adverse Events and How Intravenous (IV) Pivekimab Sunirine Moves Through the Body in Pediatric Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Enrollment
18 pts
Country
🇺🇸 United States
AbbVie
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NCT06575296 Phase 1
Recruiting

Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

Enrollment
27 pts
Country
🇺🇸 United States
City of Hope Medical Center
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NCT05732103 Phase 1, Phase 2
Recruiting

A Study of CTX-712 in Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes

Enrollment
225 pts
Country
🇺🇸 United States
Chordia Therapeutics, Inc.
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NCT04986657
Recruiting

Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS

Enrollment
325 pts
Country
🇺🇸 United States
Washington University School of Med...
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NCT04771130 Phase 1, Phase 2
Recruiting

A Study of BGB-11417 in Participants With Myeloid Malignancies

Enrollment
260 pts
Country
🇺🇸 United States
BeOne Medicines
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NCT06419634 Phase 1
Recruiting

Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Enrollment
105 pts
Country
🇺🇸 United States
Bristol-Myers Squibb
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NCT04774393 Phase 1, Phase 2
Recruiting

Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Enrollment
84 pts
Country
🇺🇸 United States
M.D. Anderson Cancer Center
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Frequently Asked Questions

How many acute myeloid leukemia clinical trials are active in United States?
There are currently 21 active clinical trials for acute myeloid leukemia with sites in United States, of which 21 are actively recruiting patients.
How can I join a acute myeloid leukemia clinical trial in United States?
To join a acute myeloid leukemia clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.
What phases are acute myeloid leukemia trials in United States?
Active acute myeloid leukemia trials in United States span Phase 4, Phase 2, Phase 1, Phase 3, Phase 1, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology