Medical Condition

recurrent glioblastoma

Total Trials

13

Recruiting Now

13

Trial Phases

Phase 1, EARLY_Phase 1, Phase 2

ClinicalMetric tracks all active clinical trials for recurrent glioblastoma sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — recurrent glioblastoma Clinical Trials

How many clinical trials are currently recruiting for recurrent glioblastoma?

ClinicalMetric currently tracks 13 actively recruiting clinical trials for recurrent glioblastoma, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 13. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for recurrent glioblastoma?

recurrent glioblastoma research spans Phase 1 (8 trials), Phase 2 (4 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a recurrent glioblastoma clinical trial?

Eligibility criteria for recurrent glioblastoma trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Top Sponsors

M.D. Anderson Cancer Center 1 trial

Shayan Moosa, MD 1 trial

Kailin Yang, MD, PhD 1 trial

Jasper Gerritsen 1 trial

Huashan Hospital 1 trial

Recruiting Clinical Trials

NCT03896568 Phase 1

Recruiting

MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

M.D. Anderson Cancer Center

View Trial →

NCT06039709 Phase 1

Recruiting

Sonodynamic Therapy in Patients With Recurrent GBM

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)

Enrollment

464 pts

Location

United States, Belgi...

Sponsor

Jasper Gerritsen

View Trial →

NCT07538128 EARLY_Phase 1

Recruiting

Evaluating Safety, Tolerability, and Preliminary Efficacy of YSCH-01 Monotherapy and in Combination With Atezolizumab for Recurrent Glioblastoma

The Efficacy and Safety of Low-dose Radiotherapy Combined With Sintilimab and Temozolomide in Recurrent Glioblastoma

Fifth Affiliated Hospital, Sun...

View Trial →

NCT07551336 Phase 1

Recruiting

Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma

Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma

Alpha Tau Medical LTD.

View Trial →

NCT07346144 Phase 1, Phase 2

Recruiting

Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma

Enrollment

68 pts

Location

United States, Unite...

Sacituzumab Govitecan in Recurrent Glioblastoma

The University of Texas Health...

View Trial →

NCT07076472 EARLY_Phase 1

Recruiting

Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma

Surgical Pembro +/- Olaparib w TMZ for rGBM

L. Nicolas Gonzalez Castro, MD...

View Trial →

NCT05432518 EARLY_Phase 1

Recruiting

Pilot Trial for Treatment of Recurrent Glioblastoma

AHS Cancer Control Alberta

View Trial →

Related Conditions

glioblastoma (5) glioblastoma multiforme (2) high grade gliomas (2) idh1 wt allele (1) recurrent anaplastic astrocytoma (1) recurrent gliosarcoma (1) recurrent malignant glioma (1) gbm (1) glioma (1) recurrent glioma (1) grade 4 malignant glioma of brain disorder (1) glioblastoma idh wildtype (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology