Anxiety disorders — including generalized anxiety disorder (GAD), social anxiety disorder, PTSD, panic disorder, and OCD — collectively represent the most prevalent psychiatric condition globally, affecting approximately 30% of adults at some point in their lives. Despite widespread availability of SSRIs, SNRIs, and benzodiazepines, substantial proportions of patients fail to achieve remission, driving an active clinical trial landscape for novel mechanisms and delivery formats.
Active trials investigate CRHR1 antagonists for stress-induced anxiety, V1b vasopressin receptor antagonists, cannabidiol formulations, MDMA-assisted psychotherapy for PTSD (Phase 3 results showed strong efficacy in two trials), ketamine infusion for severe GAD refractory to other treatments, transcranial magnetic stimulation (TMS), and digital therapeutics combining cognitive behavioral therapy with biometric monitoring. PTSD trials often recruit veterans and first responders.
Anxiety trials typically use validated rating scales (HAM-A, GADARS, CAPS-5 for PTSD) at baseline and follow-up; prior SSRIs/SNRIs trials and current benzodiazepine use are common eligibility considerations.
Frequently Asked Questions — procedural anxiety Clinical Trials
How many clinical trials are currently recruiting for procedural anxiety?
ClinicalMetric currently tracks 2 actively recruiting clinical trials for procedural anxiety, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 2. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for procedural anxiety?
procedural anxiety research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a procedural anxiety clinical trial?
Eligibility criteria for procedural anxiety trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
Boston University 1 trial
Children's Hospital Los Angeles 1 trial
Recruiting Clinical Trials
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional.
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Last Reviewed: April 2026 ·
Data Methodology