← Browse by Condition
Medical Condition

major depressive disorder mdd

Total Trials
15
Recruiting Now
15
Trial Phases
Phase 2, Phase 4, Phase 3

ClinicalMetric tracks all active clinical trials for major depressive disorder mdd sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — major depressive disorder mdd Clinical Trials

How many clinical trials are currently recruiting for major depressive disorder mdd?
ClinicalMetric currently tracks 15 actively recruiting clinical trials for major depressive disorder mdd, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 15. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for major depressive disorder mdd?
major depressive disorder mdd research spans Phase 2 (4 trials), Phase 3 (1 trial), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a major depressive disorder mdd clinical trial?
Eligibility criteria for major depressive disorder mdd trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 2
4
Phase 3
1
Phase 4
1
Top Sponsors
The University of Hong Kong 2 trials
Draig Therapeutics Ltd 1 trial
First Affiliated Hospital of Chongqing Medical University 1 trial
Université Catholique de Louvain 1 trial
Pakistan Institute of Living and Learning 1 trial

Recruiting Clinical Trials

NCT07300969 Phase 2
Recruiting
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
Enrollment
300 pts
Location
United States, Bulga...
Sponsor
Draig Therapeutics Ltd
View Trial →
NCT07539805 Phase 2
Recruiting
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression
Enrollment
60 pts
Location
China
Sponsor
First Affiliated Hospital of C...
View Trial →
NCT07925281
Recruiting
Emotional Reactivity in Severe Alcohol Use Disorder and Major Depressive Disorder Using Eye-tracking, Physiological, and Interoceptive Measures (ERAD)
Enrollment
280 pts
Location
Belgium
Sponsor
Université Catholique de Louva...
View Trial →
NCT07015944
Recruiting
Moving on After Breast Cancer Trial for Depressed Breast Cancer Survivors in Pakistan
Enrollment
26,376 pts
Location
Pakistan
Sponsor
Pakistan Institute of Living a...
View Trial →
NCT06746155
Recruiting
Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
Enrollment
252 pts
Location
Canada
Sponsor
Abraham Nunes
View Trial →
NCT07228468
Recruiting
Home-Based Transcranial Direct Current Stimulation In Major Depressive Disorder (HOME)
Enrollment
438 pts
Location
United Kingdom
Sponsor
King's College London
View Trial →
NCT06804525
Recruiting
LHC-CIDI-5 in Hong Kong
Enrollment
2,500 pts
Location
Hong Kong
Sponsor
The University of Hong Kong
View Trial →
NCT06409325
Recruiting
Effectiveness of MST Versus ECT for Major Depressive Episode
Enrollment
210 pts
Location
China
Sponsor
Shanghai Mental Health Center
View Trial →
NCT07226661 Phase 2
Recruiting
Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
Enrollment
230 pts
Location
United States
Sponsor
Supernus Pharmaceuticals, Inc.
View Trial →
NCT06675851 Phase 4
Recruiting
Reward-specific Changes of the Chemical Messenger Dopamine in the Brain of Healthy and Depressed People
Enrollment
120 pts
Location
Austria
Sponsor
Medical University of Vienna
View Trial →
NCT07604753
Recruiting
Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental Disorders
Enrollment
300 pts
Location
Hong Kong
Sponsor
The University of Hong Kong
View Trial →
NCT06958692 Phase 3
Recruiting
A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive Disorder
Enrollment
388 pts
Location
China
Sponsor
CSPC Ouyi Pharmaceutical Co., ...
View Trial →
NCT06854224 Phase 2
Recruiting
Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial
Enrollment
30 pts
Location
United States
Sponsor
Marianne Goodman
View Trial →
NCT07217223
Recruiting
Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
Enrollment
10 pts
Location
United States
Sponsor
University of California, San ...
View Trial →
NCT06692361
Recruiting
Assessment of the Efficacy and Safety of Fecal Microbiota Transplantation (FMT) in Patients With Major Depressive Disorder
Enrollment
214 pts
Location
China
Sponsor
Gang Wang
View Trial →

Related Conditions

generalized anxiety disorder gad (2) posttraumatic stress disorder ptsd (2) probiotic intervention (1) alcohol use disorder (1) breast cancer survivor (1) major depressive episode mde (1) persistent depressive disorder pdd (1) suicidal ideation (1) suicidal plan (1) suicidal attempt (1) suicidal gesture (1) nonsuicidal self injury (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology