Medical Condition

major depressive disorder mdd

Total Trials

10

Recruiting Now

10

Trial Phases

Phase 4, Phase 2

ClinicalMetric tracks all active clinical trials for major depressive disorder mdd sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — major depressive disorder mdd Clinical Trials

How many clinical trials are currently recruiting for major depressive disorder mdd?

ClinicalMetric currently tracks 10 actively recruiting clinical trials for major depressive disorder mdd, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 10. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for major depressive disorder mdd?

major depressive disorder mdd research spans Phase 2 (5 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a major depressive disorder mdd clinical trial?

Eligibility criteria for major depressive disorder mdd trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

Phase 4

Top Sponsors

Corporacion Parc Tauli 1 trial

Stony Brook University 1 trial

Draig Therapeutics Ltd 1 trial

First Affiliated Hospital of Chongqing Medical University 1 trial

Supernus Pharmaceuticals, Inc. 1 trial

Recruiting Clinical Trials

NCT07041073

Recruiting

EEG-based Neurofeedback to Improve Emotion Regulation in Major Depressive Disorder: A Randomized Clinical Trial

Corporacion Parc Tauli

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NCT07095205 Phase 4

Recruiting

PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.

Stony Brook University

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NCT07300969 Phase 2

Recruiting

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

Enrollment

300 pts

Location

United States, Bulga...

Sponsor

Draig Therapeutics Ltd

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NCT07645157 Phase 2

Recruiting

Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression

First Affiliated Hospital of C...

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NCT07226661 Phase 2

Recruiting

Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder

Supernus Pharmaceuticals, Inc.

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NCT07212465

Recruiting

Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression

Rotman Research Institute at B...

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NCT07603804

Recruiting

Accelerated iTBS for Major Depression

Istanbul University - Cerrahpa...

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NCT07562191 Phase 2

Recruiting

Inhaled DMT for Major Depressive Disorder

Universidade Federal do Rio Gr...

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NCT06976697

Recruiting

Home-Based tDCS Treatment Of Major Depressive Disorder

Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)

Related Conditions

suicidal ideation (2) major depression with comorbid anxiety symptoms (1) probiotic intervention (1) treatment resistant depression trd (1) mdd (1) major depression (1) suicide (1) borderline personality disorder bpd (1) treatment resistant major depressive disorder (1) treatment resistant bipolar depression (1) bipolar disorder bd (1) bipolar disorder i or ii (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology