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locally advanced

Total Trials
6
Recruiting Now
6
Trial Phases
Phase 1, Phase 2

ClinicalMetric tracks all active clinical trials for locally advanced sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — locally advanced Clinical Trials

How many clinical trials are currently recruiting for locally advanced?
ClinicalMetric currently tracks 6 actively recruiting clinical trials for locally advanced, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 6. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for locally advanced?
locally advanced research spans Phase 1 (3 trials), Phase 2 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a locally advanced clinical trial?
Eligibility criteria for locally advanced trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
3
Phase 2
3
Top Sponsors
Avenzo Therapeutics, Inc. 1 trial
Recursion Pharmaceuticals Inc. 1 trial
Baptist Health South Florida 1 trial
PMV Pharmaceuticals, Inc 1 trial
Hubei Cancer Hospital 1 trial

Recruiting Clinical Trials

NCT07038343 Phase 1, Phase 2
Recruiting
AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)
Enrollment
480 pts
Location
United States
Sponsor
Avenzo Therapeutics, Inc.
View Trial →
NCT06678659 Phase 1, Phase 2
Recruiting
A Study of REC-1245 in Participants With Unresectable, Locally Advanced, or Metastatic Cancer
Enrollment
170 pts
Location
United States, Canad...
Sponsor
Recursion Pharmaceuticals Inc.
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NCT05679674
Recruiting
Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer
Enrollment
48 pts
Location
United States
Sponsor
Baptist Health South Florida
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NCT04585750 Phase 1, Phase 2
Recruiting
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Enrollment
300 pts
Location
United States, Austr...
Sponsor
PMV Pharmaceuticals, Inc
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NCT06020430
Recruiting
Omitting CTV for Locally Advanced NSCLC Responded to Immunotherapy and Chemotherapy
Enrollment
134 pts
Location
China
Sponsor
Hubei Cancer Hospital
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NCT07155850
Recruiting
Early Feasibility Clinical Investigation to Assess YntraDose™ as a Neoadjuvant Treatment for LA-PDAC
Enrollment
10 pts
Location
Italy, United Kingdo...
Sponsor
BetaGlue Therapeutics SpA
View Trial →

Related Conditions

unresectable (2) her2 breast cancer (2) non small cell lung cancer (2) solid tumor cancer (1) metastatic solid tumors (1) lung cancers (1) epithelial tumor (1) biliary tract cancer btc (1) urothelial cancer (1) nasopharyngeal cancers (1) metastatic cancers (1) relapsed refractory lymphomas (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology