← Browse by Condition
Medical Condition

heart failure with reduced ejection fraction

Total Trials
7
Recruiting Now
7
Trial Phases
Phase 2, EARLY_Phase 1, Phase 3

ClinicalMetric tracks all active clinical trials for heart failure with reduced ejection fraction sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — heart failure with reduced ejection fraction Clinical Trials

How many clinical trials are currently recruiting for heart failure with reduced ejection fraction?
ClinicalMetric currently tracks 7 actively recruiting clinical trials for heart failure with reduced ejection fraction, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 7. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for heart failure with reduced ejection fraction?
heart failure with reduced ejection fraction research spans Phase 1 (1 trial), Phase 2 (1 trial), Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a heart failure with reduced ejection fraction clinical trial?
Eligibility criteria for heart failure with reduced ejection fraction trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
1
Phase 2
1
Phase 3
1
Top Sponsors
Cardiac Success 1 trial
Baylor College of Medicine 1 trial
University Hospital, Basel, Switzerland 1 trial
The University of Texas Health Science Center at San Antonio 1 trial
Pulnovo Medical (Wuxi) Co., Ltd. 1 trial

Recruiting Clinical Trials

NCT06851949 Phase 2
Recruiting
Vsling™ I: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart Failure
Enrollment
20 pts
Location
Israel
Sponsor
Cardiac Success
View Trial →
NCT05650658
Recruiting
Left vs Left Randomized Clinical Trial
Enrollment
2,136 pts
Location
United States, Canad...
Sponsor
Baylor College of Medicine
View Trial →
NCT06942221
Recruiting
Digital Solutions in Heart Therapy (DIGNITY)
Enrollment
140 pts
Location
Switzerland
Sponsor
University Hospital, Basel, Sw...
View Trial →
NCT06229678 EARLY_Phase 1
Recruiting
Ketones, SGLT2, HFrEF
Enrollment
71 pts
Location
United States
Sponsor
The University of Texas Health...
View Trial →
NCT05824923 Phase 3
Recruiting
A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hypertension Associated With Left Heart Failure
Enrollment
264 pts
Location
China
Sponsor
Pulnovo Medical (Wuxi) Co., Lt...
View Trial →
NCT05564793
Recruiting
Improving CRT Outcome With Non-Invasive Cardiac Mapping
Enrollment
330 pts
Location
Netherlands, Portuga...
Sponsor
EP Solutions SA
View Trial →
NCT06384963
Recruiting
Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF
Enrollment
54 pts
Location
Australia, New Zeala...
Sponsor
Ceryx Medical Australia
View Trial →

Related Conditions

heart failure (2) av block (1) lbbb (1) rbbb (1) intraventricular conduction delay (1) pacing induced cardiomyopathy (1) type2diabetes (1) pulmonary hypertension (1) hypertension (1) vascular diseases (1) cardiovascular diseases (1) heart failure with preserved ejection fraction (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology