Medical Condition

brain metastases

Total Trials

11

Recruiting Now

11

Trial Phases

Phase 2, Phase 1, Phase 1, Phase 2

ClinicalMetric tracks all active clinical trials for brain metastases sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — brain metastases Clinical Trials

How many clinical trials are currently recruiting for brain metastases?

ClinicalMetric currently tracks 11 actively recruiting clinical trials for brain metastases, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 11. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for brain metastases?

brain metastases research spans Phase 1 (4 trials), Phase 2 (6 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a brain metastases clinical trial?

Eligibility criteria for brain metastases trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 4

Top Sponsors

University of Utah 2 trials

M.D. Anderson Cancer Center 1 trial

Dartmouth-Hitchcock Medical Center 1 trial

University of Louisville 1 trial

Baptist Health South Florida 1 trial

Recruiting Clinical Trials

NCT06649058 Phase 2

Recruiting

EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

M.D. Anderson Cancer Center

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NCT05139277

Recruiting

Evaluation of the CONVIVO System

Dartmouth-Hitchcock Medical Ce...

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NCT07044557

Recruiting

MeDex: No Perioperative Dexamethasone in Brain Metastases

University of Louisville

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NCT02390518 Phase 1

Recruiting

Stereotactic Radiosurgery Dose Escalation for Brain Metastases

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

Baptist Health South Florida

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NCT07248228 Phase 2

Recruiting

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

Case Comprehensive Cancer Cent...

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NCT06620380 Phase 2

Recruiting

Ex Vivo Drug Response Evaluation for Next Generation Care of Brain Metastases

NCT06194929 Phase 1, Phase 2

Recruiting

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

Washington University School o...

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NCT06243003 Phase 1, Phase 2

Recruiting

WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases

Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer

Weill Medical College of Corne...

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Related Conditions

brain metastases adult (2) glioblastoma (1) glial tumor (1) meningioma (1) schwannoma (1) pituitary tumor (1) brain cancer (1) cutaneous melanoma (1) central nervous system cancer (1) sclc extensive stage (1) breast cancer (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology