anxiety disorders
Anxiety disorder trials span generalized anxiety disorder (GAD), social anxiety disorder, PTSD, OCD, and panic disorder, with increasing interest in neurobiological targets beyond serotonin and GABA systems. PTSD research has been particularly active following MDMA-assisted therapy trials showing striking efficacy in Phase 3 studies.
Trials evaluate CRHR1 antagonists, V1b antagonists, cannabidiol formulations, MDMA-assisted psychotherapy, exposure-based digital therapeutics, and transcranial magnetic stimulation. PTSD trials often recruit veterans and first responders through VA and DoD partnerships.