Vaginal Microbiome and HPV Pre-malignant and Cervical Dysplasia
Trial Parameters
Brief Summary
In this study, the investigators will prospectively collect, analyze and integrate information regarding vaginal microbiome composition and HPV presence in women with cervical pathologies (high-grade CIN and CC) and controls, to construct a large dataset from patients with pre-cancerous cervical lesions and healthy women, to evaluate the personalized contribution of the vaginal microbiome to the CIN-CC sequence.
Eligibility Criteria
Inclusion Criteria: * Age 25-70 * Attended the clinic for a Pap smear or colposcopy Exclusion Criteria: * Patient does not approve sample collection * Usage of antibiotics in the month prior to clinic visit * Usage of any vaginal preparation or medication in the week prior to sample collection (anti-fungal, spermicides, lubricant etc.) * Menstruation * Pregnancy