NCT07399977 Using a Blood Test and Software Tool to Guide Treatment for Venous Thromboembolism
| NCT ID | NCT07399977 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Memorial Sloan Kettering Cancer Center |
| Condition | Venous Thromboembolism |
| Study Type | INTERVENTIONAL |
| Enrollment | 259 participants |
| Start Date | 2026-01-30 |
| Primary Completion | 2030-01-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 259 participants in total. It began in 2026-01-30 with a primary completion date of 2030-01-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to find out whether a software tool, ctDNA/VTE (Venous Thromboembolism) risk score model, is an effective way to predict the likelihood of VTE coming back in people who have received anticoagulant treatment.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 with a history of cancer-associated VTE (objectively confirmed symptomatic or incidental/unsuspected proximal lower-limb DVT, symptomatic pulmonary embolism \[PE\] or incidental PE in a segmental or more proximal pulmonary artery) and completion of between 3 and 12 months of anticoagulation with enoxaparin, dalteparin,rivaroxaban, or apixaban without current VTE-related symptoms (imaging to confirm resolution not required). Diagnosis of DVT requires evidence of one or more filling defects at compression ultrasonography, venography, CT venography, or MR venography involving at least the popliteal or more proximal veins. Diagnosis of PE requires an intraluminal filling defect in segmental or more proximal arteries. * Diagnosis of one of the following solid tumors in either advanced (i.e. unresectable) stage or receiving systemic anticancer treatment within six weeks of enrollment (maintenance therapy included): * breast cancer regardless of cytotoxic-chemotherapy status * hepatobiliary cancer regardless of cytotoxic-chemotherapy status * prostate cancer regardless of cytotoxic-chemotherapy status * non-small cell lung cancer with cytotoxic-chemotherapy received within 30 days * pancreatic cancer with cytotoxic-chemotherapy received within 30 days * bladder cancer with cytotoxic-chemotherapy received within 30 days * Signed and dated informed consent by study participant/Legally Authorized Representative (LAR). Exclusion Criteria: * Contraindication to ongoing anticoagulation * Contraindication to discontinuation of anticoagulation (examples include but not limited to: known antiphospholipid syndrome or factor V leiden, active arterial thrombus, catheter-associated thrombus, on anticoagulation for atrial fibrillation or other non-oncologic reasons) * History of major bleeding in the last six months (major bleeding defined as fatal bleeding, and/or symptomatic bleeding in a critical area or organ, such as intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, or intramuscular with compartment syndrome; bleeding that necessitates acute surgical intervention; bleeding causing a fall in hemoglobin levels of 1.24 mmol/L (2 g/dL or greater) or more; or bleeding leading to a transfusion of 2 U or more of whole blood or red cells). * Known diagnosis of disseminated intravascular coagulation (DIC) * Suspicion for tumor thrombus on the imaging leading to original diagnosis of VTE * Enrolled in hospice care * Currently has inferior vena cava (IVC) filter * Diagnosis of an active hematologic malignancy
Contact & Investigator
Justine Jee, MD, PhD
PRINCIPAL INVESTIGATOR
Memorial Sloan Kettering Cancer Center
Frequently Asked Questions
Who can join the NCT07399977 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Venous Thromboembolism. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07399977 currently recruiting?
Yes, NCT07399977 is actively recruiting participants. Contact the research team at jeej@mskcc.org for enrollment information.
Where is the NCT07399977 trial being conducted?
This trial is being conducted at Basking Ridge, United States, Middletown, United States, Montvale, United States, Commack, United States and 4 additional locations.
Who is sponsoring the NCT07399977 clinical trial?
NCT07399977 is sponsored by Memorial Sloan Kettering Cancer Center. The principal investigator is Justine Jee, MD, PhD at Memorial Sloan Kettering Cancer Center. The trial plans to enroll 259 participants.