NCT04189965 Traumatic Long-term Memory of Pain in Humans
| NCT ID | NCT04189965 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Hospices Civils de Lyon |
| Condition | Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 180 participants |
| Start Date | 2021-01-11 |
| Primary Completion | 2027-02 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 180 participants in total. It began in 2021-01-11 with a primary completion date of 2027-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Few studies have focused on understanding the mechanisms underlying pain memory in humans. Thus, this project aims to investigate the link between pain memorisation and memorisation of the associated context by addressing the issue of pain conditioning. The study is composed of two successive parts: one pilot then one experimental. The goal is to understand pain memorisation processes by analysing the parallel between pain memorisation and memorisation of a traumatic event. By using immersive virtual reality, investigators aim to show that contextual pain conditioning is associated with : 1- a specific neural networks; 2- a reactivation of vegetative and behavioural reactions related to pain as well as electro-physiological markers when re-exposure to the specific pain-conditioning-context; 3- an implicit hypermnesia of the pain-associated context and a struggle to extinguish conditioning; 4- a favoured elaboration of false memories of the contextual pain. The emitted hypothesis suggests that a cortical and behavioural mnemonic trace is created during encoding of pain in association with its context, and that the latter can reactivate although the pain itself has disappeared. This implicit cortical mnemonic trace, evoked by the simple pain-associated context, could explain the notion of pain print persisting at long-term in patients suffering from chronic pain.
Eligibility Criteria
Inclusion Criteria: * Healthy subject * Subject between 18 and 50 years old * Subjects having given their written consent * Subjects with health insurance Exclusion Criteria: * Prior addiction to drugs * Prior neurological issues * Chronic pain (neuropathic or non-neuropathic) * Pregnant/breast-feeding women * Absence of efficient contraception method for the duration of the study (1 month) for participants of procreation age (no inclusion limitation for male participants of procreation age) * Subjects under chronic analgesic treatment or having taken an analgesic treatment in the 24 h preceding the experiment * Heart issues * Subjects under justice surveillance * Subjects participating in another study which inclusion period overlaps with the one from this study
Contact & Investigator
Frequently Asked Questions
Who can join the NCT04189965 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04189965 currently recruiting?
Yes, NCT04189965 is actively recruiting participants. Contact the research team at luis-jose.garcia-larrea@chu-lyon.fr for enrollment information.
Where is the NCT04189965 trial being conducted?
This trial is being conducted at Bron, France.
Who is sponsoring the NCT04189965 clinical trial?
NCT04189965 is sponsored by Hospices Civils de Lyon. The trial plans to enroll 180 participants.