Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study
Trial Parameters
Brief Summary
Alcohol use disorder (AUD) is a complex chronic brain disease characterized by compulsive alcohol use, loss of control over drinking, and negative emotional states. Extensive research has identified the general neural circuitry underlying AUD. There is an exciting opportunity to intervene in AUD using neuromodulation. Transcranial magnetic stimulation (TMS) offers a non-invasive method to modulate brain activity, making it a promising tool for investigating, modulating, and potentially treating AUD. However, the precise effects of TMS on neural circuits involved in AUD and the mechanisms underlying these effects must first be understood. Magnetoencephalography (MEG) is a neuroimaging method that provides direct measurement of brain activity within neural circuits with high temporal resolution. Critically, MEG can measure brain activity in a wide range of frequencies that are consistent with those targeted by TMS. The goal of this proposal is therefore to collect preliminary and feasibility data to support a future NIH grant application that would use MEG to investigate TMS effects in individuals with AUD (iAUD).
Eligibility Criteria
Inclusion Criteria non-AUD Participants: * Diagnostic and Statistical Manual of Mental Disorders (DSM-5) score for AUD = 0 * Alcohol Use Disorders Identification Test (AUDIT) score ≤ 7 * Is not a heavy alcohol consumer Inclusion Criteria AUD Participants: * DSM-5 score for AUD ≥ 3 * AUDIT score ≥ 8 * Is a heavy alcohol consumer Exclusion Criteria: * Current substance use disorder other than alcohol use disorder and/or frequent use of non-prescribed psychoactive substances. * Current serious psychiatric disorder, and/or any history of a psychotic disorder * Any health problem that would interfere with the study or could be aggravated by study procedures (e.g., history of migraines, claustrophobia). * Is currently taking or initiates a medication known to affect alcohol intake and/or craving. * History of traumatic brain injury resulting in hospitalization, loss of consciousness, and/or having ever been informed he/she has an epidural, subdural, or subarachnoid hemorrhage. * Does not mee