NCT07336251 Transcranial Magnetic Stimulation in Veterans With PTSD
| NCT ID | NCT07336251 |
| Status | Recruiting |
| Phase | — |
| Sponsor | White River Junction Veterans Affairs Medical Center |
| Condition | PTSD - Post Traumatic Stress Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2026-01-15 |
| Primary Completion | 2027-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2026-01-15 with a primary completion date of 2027-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
With this research investigators hope to begin to understand how rTMS can improve posttraumatic stress disorder (PTSD) symptoms. TMS improves PTSD through two interrelated mechanisms: change in brain limbic system function and change in systemic inflammatory activation. Participants who decide to join this study, will receive ten rTMS treatments. All participants will undergo a 40-minute rTMS procedure with a member of the study team 10 times over 2-4 weeks. Participants will undergo fMRI scans of the head in order to help researchers better understand potential effects of rTMS on brain activity. In addition, participants will be asked to give two breath and blood samples to look for signs of general inflammation.
Eligibility Criteria
Inclusion Criteria: * Age between 19 and 70 * Eligible for VA healthcare * Moderate to severe PTSD as determined by a total score of at least 25 on the CAPS within 7 days of randomization. * Agree to have CAPS audio recorded. * Ability to obtain a Motor Threshold using the TMS device during screening. * If female with childbearing potential, use of acceptable method of birth control (i.e., use of contraceptives, abstinence). * Able to read, understand, and sign the informed consent document. Exclusion Criteria: * Pregnant or lactating woman. * MRI is contraindicated * Current use of clozapine (any dose) or bupropion (more than 300mg per day). * Cardiac pacemaker or implantable defibrillator. * Presence of any metal object in the head, including cochlear implants, but excluding dental work in the mouth. * Significant central nervous system disorder (stroke, brain mass, epilepsy). * Seizure in past one year. * Current psychosis or mania. * Significant suicidal ideation. * Unstable medical conditions. * Current alcohol or substance use disorder (except nicotine) that interferes with the patient's ability to participate. * CPT or PE for PTSD in the past 2 months. * Changes in Fluoxetine, Paroxetine, Sertraline, or Venlafaxine in the past 2 months. * Color blind * Currently participating in other research studies. * Aneurysm Clip * Ocular foreign body (e.g., metal shavings) * Any implanted device (pumps, infusion devices, etc.) * Shrapnel injuries or metal fragments
Contact & Investigator
Bradley Watts
PRINCIPAL INVESTIGATOR
US Department of Veterans Affairs
Frequently Asked Questions
Who can join the NCT07336251 clinical trial?
This trial is open to participants of all sexes, aged 19 Years or older, up to 70 Years, studying PTSD - Post Traumatic Stress Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07336251 currently recruiting?
Yes, NCT07336251 is actively recruiting participants. Contact the research team at bradley.watts@va.gov for enrollment information.
Where is the NCT07336251 trial being conducted?
This trial is being conducted at White River Junction, United States.
Who is sponsoring the NCT07336251 clinical trial?
NCT07336251 is sponsored by White River Junction Veterans Affairs Medical Center. The principal investigator is Bradley Watts at US Department of Veterans Affairs. The trial plans to enroll 20 participants.
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