NCT07146438 Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder
| NCT ID | NCT07146438 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Adam Frank |
| Condition | Obsessive - Compulsive Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 48 participants |
| Start Date | 2025-11-10 |
| Primary Completion | 2028-06 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 48 participants in total. It began in 2025-11-10 with a primary completion date of 2028-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study will test how people with OCD respond to a type of noninvasive brain stimulation, repetitive Transcranial Magnetic Stimulation (rTMS), when it is combined with psychotherapy. Participants will either engage in Exposure and Response Prevention (ERP) Therapy or supportive therapy (ST) while receiving rTMS. Biobehavioral data from wearable devices and smartphones will be collected to better predict treatment responses. Participants will also undergo repeat resting state functional Magnetic Resonance Imaging (rsfMRI) in order to assess neural predictors and mechanisms of treatment response.
Eligibility Criteria
Inclusion Criteria: * Diagnosis of Obsessive-Compulsive Disorder (OCD) as determined by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria. * Live in Southern California and be willing to attend in-person to receive repetitive Transcranial Magnetic Stimulation (rTMS) 5 times per week for 6 weeks. * Have completed a prior course of Exposure and Response Prevention (ERP) therapy (at least ten sessions) * Currently take or have previously tried Serotonin Reuptake Inhibitor (SRI) medication for OCD * Willing to maintain psychotropic medication levels throughout the 16 weeks of the study Exclusion Criteria: * Primary psychiatric diagnosis other than OCD * Active substance use disorder * Active suicidality * Active psychosis * History of seizures * Severe neurological impairment * Pregnant or planning to become pregnant * Received a prior rTMS course
Contact & Investigator
Adam C. Frank, MD, PhD
PRINCIPAL INVESTIGATOR
Keck School of Medicine of USC
Frequently Asked Questions
Who can join the NCT07146438 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Obsessive - Compulsive Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07146438 currently recruiting?
Yes, NCT07146438 is actively recruiting participants. Contact the research team at frankocdlab@usc.edu for enrollment information.
Where is the NCT07146438 trial being conducted?
This trial is being conducted at Los Angeles, United States.
Who is sponsoring the NCT07146438 clinical trial?
NCT07146438 is sponsored by Adam Frank. The principal investigator is Adam C. Frank, MD, PhD at Keck School of Medicine of USC. The trial plans to enroll 48 participants.