NCT06782191 TMJ Arthroscopic Lysis and Lavage Compared to Operative Arthroscopy in Disc Displacement With Reduction.
| NCT ID | NCT06782191 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Karolinska Institutet |
| Condition | Temporomandibular Joint Disc Displacement, With Reduction |
| Study Type | INTERVENTIONAL |
| Enrollment | 96 participants |
| Start Date | 2025-04-01 |
| Primary Completion | 2029-02 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 96 participants in total. It began in 2025-04-01 with a primary completion date of 2029-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to compare the intervention arthroscopic lysis and lavage to the intervention operative arthroscopy in treating disabling and painful temporomandibular joint disc displacement with reduction. The main questions it aims to answer are: * Which surgical method that best improves mouth opening capacity, TMJ pain, and TMJ disability? * If any pre- or peri-operative variable/-s could be identified as a predictor for surgical outcome? Researchers will compare arthroscopic lysis and lavage to operative arthroscopy to see if operative arthroscopy works better to treat temporomandibular joint disc displacement. Participants will: * Have one of the two interventions under general anesthesia, not knowing which intervention. * Visit an external clinic for regular checkups at 1, 3, 6, 12, and 24 months after surgery. * Answer three different quality of life surveys at the checkups.
Eligibility Criteria
Inclusion Criteria: * Uni- or bilateral DDwR verified with clinical and magnetic resonance imaging (MRI) findings * TMJ pain ≥ 3 (NRS) and/or TMJ disability ≥ 3 (NRS) * Age ≥ 18 years Exclusion Criteria: * Prior open TMJ surgery * Patient diagnosed with rheumatologic joint disease * ASA (American Society of Anaesthesiologists) \> 3 * Patient unable to verify informed consent
Contact & Investigator
Mattias Ulmner, DDS, PhD
PRINCIPAL INVESTIGATOR
Karolinska Institutet, Department of Dental Medicine
Frequently Asked Questions
Who can join the NCT06782191 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Temporomandibular Joint Disc Displacement, With Reduction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06782191 currently recruiting?
Yes, NCT06782191 is actively recruiting participants. Contact the research team at mattias.ulmner@ki.se for enrollment information.
Where is the NCT06782191 trial being conducted?
This trial is being conducted at Huddinge, Sweden.
Who is sponsoring the NCT06782191 clinical trial?
NCT06782191 is sponsored by Karolinska Institutet. The principal investigator is Mattias Ulmner, DDS, PhD at Karolinska Institutet, Department of Dental Medicine. The trial plans to enroll 96 participants.