NCT07510061 Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
| NCT ID | NCT07510061 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Thessaly |
| Condition | Skin Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 80 participants |
| Start Date | 2025-11-01 |
| Primary Completion | 2027-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 80 participants in total. It began in 2025-11-01 with a primary completion date of 2027-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans. Excess morbidity and mortality during heat waves provides strong evidence for fatal outcomes. However, it is unclear why some people are particularly vulnerable and get sick from hyperthermia, while others adapt and tolerate exposure. The Icarus project aims to provide a psycho-physiological framework for improved mitigation of the health threats associated with global warming. Combining expertise in integrative thermal physiology, pharmacology, photobiology, psychology and machine learning, we will collaborate on comprehensive cross-scientific studies using controlled lab-exposure combined with investigations in ecological settings including vulnerable and highly tolerant people across populations from northern to southern Europe. Advanced algorithms will be developed to generate personalized alerts and advising based on behavioral patterns, psychological profiling, predicted vulnerability and willingness to adopt resilience-building strategies. Global warming is projected to continue towards the end of the 21st century and constitutes an increasing threat to human health unless we as individuals and collectively become better in preventing acute effects, as well as devise sustainable strategies to limit further anthropogenic warming of the climate system. Acutely, improved guidance is important for both individual and public health, where Icarus aims at providing a highly improved basis for preventing heat-related disease, advising or nudging people towards pro-health behavior, including smarter use of technologies to mitigate heat stress, or adjusting medication to reduce adverse effects during heat events. In support of the sustainability agenda, our framework also forms a novel basis for developing advising algorithms relevant for optimization of climate change mitigation policy-making.
Eligibility Criteria
Study Population Healthy adult volunteers residing in Denmark (Northern Europe) or Greece (Southern Europe). Inclusion Criteria * Age 18-65 years (or your protocol-specific age range) * Healthy as determined by medical history screening questionnaire * Able to provide written informed consent * Able to complete heat exposure and light exercise protocol * No heat acclimatization or extensive sun exposure in the previous 4 weeks * Fitzpatrick skin type I-IV (if applicable for UV testing) * Willing to undergo blood sampling, urine collection, and skin biopsy Exclusion Criteria * History of cardiovascular, metabolic, neurological, or dermatological disease * History of heat-related illness (e.g., heat stroke) * Use of medications affecting thermoregulation or cardiovascular function * Smoking or substance abuse * Pregnancy or breastfeeding * Abnormal ECG or uncontrolled hypertension * Recent severe sunburn or UV treatment * Contraindications to skin biopsy * Inability to tolerate heat exposure during screening
Contact & Investigator
Andreas D Flouris, PhD
PRINCIPAL INVESTIGATOR
1FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece
Frequently Asked Questions
Who can join the NCT07510061 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Skin Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07510061 currently recruiting?
Yes, NCT07510061 is actively recruiting participants. Contact the research team at mvliora@gmail.com for enrollment information.
Where is the NCT07510061 trial being conducted?
This trial is being conducted at Copenhagen, Denmark, Trikala, Greece.
Who is sponsoring the NCT07510061 clinical trial?
NCT07510061 is sponsored by University of Thessaly. The principal investigator is Andreas D Flouris, PhD at 1FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece. The trial plans to enroll 80 participants.
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