| NCT ID | NCT07237022 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universitaire Ziekenhuizen KU Leuven |
| Condition | Physiological Responses |
| Study Type | OBSERVATIONAL |
| Enrollment | 20 participants |
| Start Date | 2025-10-08 |
| Primary Completion | 2026-05-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 20 participants in total. It began in 2025-10-08 with a primary completion date of 2026-05-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study aims to characterize the vascular response upon topical application of cinnamaldehyde, allyl isothiocyanate and capsaicin on feet skin in healthy volunteers. The vascular response will be characterized in terms of response over time, dose-response, inter-foot and inter-period reproducibility.
Eligibility Criteria
Inclusion Criteria: 1. Subject is a white male or female ≥18 and ≤45 years of age 2. Subject is a non-smoker for at least 6 months prior to the start of the study 3. Subject has a body mass index (BMI) between 18-30 kg/m² 4. Subject is judged to be in good general health on the basis of medical history, physical examination and vital signs 5. Subject understands the procedures and agrees to participate in the study by giving written informed consent. Exclusion Criteria: 1. Subject has a history of any illness or disorder which, in the investigator's opinion, might confound the results of the study 2. Subject has a history of significant severe (drug) allergies 3. Subject is a female who is pregnant, breast-feeding or intends to become pregnant, or is of child-bearing potential and is not using an adequate contraceptive method 4. Subject uses any prescription or non-prescription drugs on a regular basis which, in the investigator's opinion, might confound the results of the study 5. Subject currently uses lotions, oils, depilatory preparations, makeup, or other topical treatments on the feet on a regular basis which cannot be discontinued for the duration of the study 6. Subject has eczema, scleroderma, psoriasis, dermatitis or keloids, tumors, ulcers, burns, skin flaps or grafts on the volar surface of the forearm or the dorsum of the feet, or any other skin abnormality that, in the opinion of the investigator, may interfere with the study assessments 7. Subject has excessive hair growth on the volar surface of the forearms or the dorsum of the feet 8. Subject has any of the following vital sign measurements at screening after at least 10 minutes of supine rest: Heart Rate \<40 or \>100 beats/min, Diastolic Blood Pressure \<50 or \>90 mmHg, Systolic Blood Pressure \<90 or \>140 mmHg 9. Subject is unable to refrain from drinking caffeinated beverages (e.g. coffee, tea, cola, …) 24 hours prior to each study visit. Subject is unable to limit their intake of caffeinated beverages to ≤4 cups a day throughout the study 10. Subject is unable to refrain from drinking alcohol 24 hours prior to each study visit, is currently a regular user of illegal drugs, or has a history of substance abuse (including alcohol) 11. Subject is currently participating or has been involved in testing an investigational drug in another clinical study within the last 4 weeks 12. Subject is in a situation or has a condition which, in the opinion of the investigator, may interfere with safe and optimal participation in the study
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07237022 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 45 Years, studying Physiological Responses. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07237022 currently recruiting?
Yes, NCT07237022 is actively recruiting participants. Contact the research team at heleen.marynissen@uzleuven.be for enrollment information.
Where is the NCT07237022 trial being conducted?
This trial is being conducted at Leuven, Belgium.
Who is sponsoring the NCT07237022 clinical trial?
NCT07237022 is sponsored by Universitaire Ziekenhuizen KU Leuven. The trial plans to enroll 20 participants.