The Effects of Chicory Root-derived Prebiotic on Mood and Stress Responsiveness in Healthy Adults With Mild to Moderate Levels of Stress and Anxiety
Trial Parameters
Brief Summary
Emerging evidence from preclinical research suggests that prebiotic fibres may play a beneficial role in supporting mental health through modulation of the gut-brain axis-a complex communication network linking the gastrointestinal tract and the central nervous system. Chicory root-derived prebiotic fibre, already well-established for its positive effects on glycaemic control and bowel regularity, has recently shown promise in this context. The present study aims to investigate the mental health benefits of chicory root fibre in a larger and more diverse population, thereby contributing to the growing body of evidence supporting nutritional strategies for mental well-being.
Eligibility Criteria
Inclusion Criteria: 1. Volunteer is healthy at the time of screening. 2. TICS Screening Scale of Chronic Stress (SSCS) score ≥ 6. 3. GAD total score ≥ 5 and ≤ 14 indicating mild to moderate anxiety. 4. Male or female aged ≥18 and ≤ 70 years at the time of screening. 5. Body-Mass-Index (BMI) ≥ 18.5 and ≤ 29.9 kg/m2. 6. Volunteer is able and willing to comply with the study instructions. 7. Volunteer is suitable for participation in the study according to the investigator/study personnel. 8. Voluntary, written informed consent to participate in the study. Exclusion Criteria: 1. No command of local language. 2. Previously or currently diagnosed neurological or psychiatric disorders. 3. Previous history of renal, hepatic, cardiovascular disease or clinically significant diabetes. 4. Gastrointestinal disorders including irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) or other conditions that might affect the gut environment. 5. Contraindication or allergy to any substance i